{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:42:19Z","timestamp":1787496139057,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T00:00:00Z","timestamp":1327449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the capability of three\u2010dimen\u2010sional (3D) reconstructed images produced by high\u2010resolution episcopic microscopy (HREM) with that of in\u2010vivo four\u2010dimensional high\u2010resolution transvaginal sonography (4D\u2010HRTVS) to discern morphological features of the first\u2010trimester human fetal heart.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective study of fetal hearts between 9 and 14 weeks' gestation. For ex\u2010vivo 3D analysis, 30 human fetal hearts (at 9 + 0 to 14 + 6 weeks) were retrieved from surgical terminations of pregnancy. The specimens were embedded in resin and episcopic (\u2018block\u2010face\u2019) imaging was used to obtain a digital volume dataset (HREM) using 3\u2010micron slicing. 4D\u2010HRTVS was performed in 28 separate pregnancies at 10 + 2 to 14 + 0 weeks using a Voluson E8 ultrasound machine with volumetric transvaginal RIC 6\u201312\u2010MHz transducers. Heart volumes obtained by both methods were compared to assess their ability to demonstrate first\u2010trimester cardiac morphology. Comparisons were made in the transverse and sagittal planes, and using volume rendering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All hearts were structurally normal, although abdominal situs was not examined in the isolated hearts that underwent HREM. 4D\u2010HRTVS demonstrated each of the complete five transverse cardiac views in 32\u201386% of cases. HREM showed four features unique to the first\u2010trimester human heart: prominent atrial appendages, spiral ventricular arrangement, prominent coronary arteries and thickened arterial walls. 4D\u2010HRTVS could demonstrate the first two, but ultrasound resolution was too poor to quantify wall thickness and demonstrate coronary arteries in the 3\u20135\u2010mm diameter heart.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>4D\u2010HRTVS showed limited morphological features of the first\u2010trimester fetal heart compared with HREM. HREM provides a gold standard of ex\u2010vivo imaging against which developments in ultrasound resolution could be compared. Copyright \u00a9 2012 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.9068","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T04:46:08Z","timestamp":1307076368000},"page":"196-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of\n                    <i>ex\u2010vivo<\/i>\n                    high\u2010resolution episcopic microscopy with\n                    <i>in\u2010vivo<\/i>\n                    four\u2010dimensional high\u2010resolution transvaginal sonography of the first\u2010trimester fetal heart"],"prefix":"10.1002","volume":"39","author":[{"given":"L.","family":"Gindes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Achiron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Mohun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Gardiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-005-0073-x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp511"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.06040240.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.77.1.68"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11030180.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2006.25.2.173"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3948"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7176.81"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00733.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00414.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00801.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2257"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1994.13.10.783"},{"key":"e_1_2_6_15_2","first-page":"69","article-title":"First\u2010trimester diagnosis of fetal congenital heart disease by trans\u2010vaginal ultrasonography","volume":"84","author":"Achiron R","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2071"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6374"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8844"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.796698"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.9068","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.9068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:59:52Z","timestamp":1700567992000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.9068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,25]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1002\/uog.9068"],"URL":"https:\/\/doi.org\/10.1002\/uog.9068","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,25]]},"assertion":[{"value":"2011-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}