{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:54:10Z","timestamp":1787504050845,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Equine pituitary pars intermedia dysfunction (PPID) is treated with daily pergolide therapy. Owner compliance and its effect on PPID control have not been previously investigated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Clinical records were searched to identify the sample of animals with PPID treated with pergolide from 2016 to 2019. The signalment was noted and the dose of pergolide received calculated. Animals were classified as compliant (receiving \u226590% of the veterinarian recommended dose of pergolide) or non\u2010compliant, and as controlled (follow\u2010up basal adrenocorticotrophic hormone concentrations within the reference range) or not.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    In total, 110 animals were included. The majority (85%) were \u226516 years (mean \u00b1 SD 19.8 \u00b1 4.4 years); the most common breeds were Cob (18%), Thoroughbred (16%) and Welsh (15%); 37% were female and 63% male. Overall, 48% were compliant and 52% non\u2010compliant. There was no significant effect of compliance on laboratory control. Of those that were compliant, 74% were controlled, while 67% of non\u2010compliant animals were controlled. Univariable analysis revealed a significant (p &lt; 0.001) effect of age and breed on compliance and control, and of sex on control. On multivariable analysis, only age (compliance) and breed (compliance and control) were retained in the final model.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Only half of animals received the recommended pergolide dose; however, this did not affect laboratory control of PPID.\n                  <\/jats:p>","DOI":"10.1002\/vetr.142","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T02:00:45Z","timestamp":1616551245000},"source":"Crossref","is-referenced-by-count":11,"title":["Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction"],"prefix":"10.1002","volume":"189","author":[{"given":"Natalie","family":"Hague","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College  Hawkshead Lane North Mymms UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Durham","sequence":"additional","affiliation":[{"name":"Liphook Equine Hospital  Liphook Hampshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3803-8069","authenticated-orcid":false,"given":"Nicola J.","family":"Menzies\u2010Gow","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College  Hawkshead Lane North Mymms UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00213.x"},{"issue":"11","key":"e_1_2_6_3_1","first-page":"CD000011","article-title":"Interventions for enhancing medication adherence","volume":"2014","author":"Nieuwlaat R","year":"2014","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e318032937e"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.226.567"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1996.tb07566.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1996.tb13774.x"},{"key":"e_1_2_6_8_1","first-page":"73","article-title":"How can veterinarians optimize owner compliance with medication regimes?","volume":"18","author":"Verker JM","year":"2008","journal-title":"Eur J Companion Anim Pract."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2010.12.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00578.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2009.01.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12339"},{"issue":"52","key":"e_1_2_6_13_1","first-page":"16","article-title":"Efficacy of a novel palatable pergolide paste formulation for the treatment of pituitary pars intermedia dysfunction (PPID) in ponies","volume":"50","author":"Rendle DI","year":"2018","journal-title":"Equine Vet J."},{"key":"e_1_2_6_14_1","unstructured":"AdamsAA SiardMH ReedySE LittleJP GrubbsS LittleMP.Does Equine Pituitary Pars Intermedia Dysfunction (PPID) Affect Immune Responses to Vaccination?. Paper presented at Dorothy Russell Havemeyer Foundation Equine Geriatric Workshop II and 3rd Equine Endocrine Summit; 17\u201020 November 2014; Middleburg VA."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2002.tb02418.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.12130"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2011.00444.x"},{"issue":"44","key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/evj.12145_48","article-title":"Effects of pergolide mesylate on plasma adrenocorticotropic hormone concentration in horses with pituitary pars intermedia dysfunction","volume":"45","author":"Rendle DI","year":"2013","journal-title":"Equine Vet J."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516402776250333"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2016.11.003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2018.03.002"},{"key":"e_1_2_6_22_1","unstructured":"DurhamAE ShreeveH.Horse factors influencing the seasonal increase in plasma ACTH secretion. Paper presented at: Dorothy Russell Havemeyer Foundation Equine Endocrinology Summit;2017; Miami FL.https:\/\/sites.tufts.edu\/equineendogroup\/files\/2017\/01\/2017-Equine-Endocrinology-Summit-D-Russell-Havemeyer-Foundation.pdf"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2020.102937"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.149.14.417"},{"issue":"11","key":"e_1_2_6_25_1","first-page":"420","article-title":"A survey of aged horses in Queensland, Australia","volume":"88","author":"McGowan TW","year":"2010","journal-title":"Part 1: management and preventive health care. Aust Vet J."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2010.00142.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.03.021"},{"key":"e_1_2_6_28_1","unstructured":"MacKay C Client compliance - The key to successful veterinary practice. 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