{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:59:48Z","timestamp":1788328788075,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T00:00:00Z","timestamp":1650672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003551","name":"Royal Canin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Twice daily low trilostane doses have proven to be effective to manage canine Cushing's syndrome. However, survival and prognostic factors in dogs treated with this protocol have not been evaluated. The aim of the study was to evaluate survival and prognostic factors, including systolic blood pressure (SBP) at diagnosis, in dogs with pituitary\u2010dependent hypercortisolism (PDH) treated with low trilostane doses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of 91 dogs newly diagnosed with PDH initially treated with 0.2\u20131.1\u00a0mg\/kg of trilostane twice daily were retrospectively included. Survival times were calculated using the Kaplan\u2013Meier estimator. Univariable and multivariable analysis were performed using the Cox proportional hazard regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, median survival was 998 days (range 26\u20131832 days, 95% confidence interval\u00a0=\u00a0755\u20131241 days). In the multivariable analysis, age (hazard ratio [HR]\u00a0=\u00a01.337,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), presence of calcinosis cutis (HR\u00a0=\u00a05.271,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), body condition score (BCS) \u22643\/9 (HR\u00a0=\u00a08.100,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and higher platelet count (HR\u00a0=\u00a01.002,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.022) were negatively correlated with survival. SBP was not associated with survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low\u2010dose trilostane treatment twice daily provides slightly longer survival than previously reported for dogs with PDH treated once or twice daily at higher doses. Older age, presence of calcinosis cutis, low BCS and higher platelet count, but not systemic hypertension, are predictive of poorer prognosis in dogs with PDH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.1630","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T15:58:34Z","timestamp":1650729514000},"source":"Crossref","is-referenced-by-count":12,"title":["Survival of dogs with pituitary\u2010dependent hyperadrenocorticism treated twice daily with low doses of trilostane"],"prefix":"10.1002","volume":"191","author":[{"given":"Paula","family":"Garc\u00eda San Jos\u00e9","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery Veterinary School Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Arenas Bermejo","sequence":"additional","affiliation":[{"name":"AniCura Hospital Veterinario Valencia Sur  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Alonso\u2010Miguel","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery Veterinary School Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Gonz\u00e1lez Sanz","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Clares Moral","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5811-9536","authenticated-orcid":false,"given":"Miriam","family":"Portero Fuentes","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery Veterinary School Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"P\u00e9rez\u2010Alenza","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery Veterinary School Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(78)90010-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2018.09.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12303"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5326\/0420269"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.150.26.799"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.161.24.805"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102546"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.105159"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2005.tb02769.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1942"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3582"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.238.11.1441"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12192"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15331"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03005.x"},{"key":"e_1_2_10_18_1","unstructured":"IRIS. 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