{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T07:23:09Z","timestamp":1777360989477,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : While often grouped with other noise aversions, fearful behaviour during storms is considered more complex than noise aversion alone. The objective here was to assess the effect of imepitoin for the treatment of storm anxiety in dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : In this double\u2010blind, placebo\u2010controlled randomised study, eligible dogs completed a baseline then were randomised to receive either imepitoin (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a030; 30\u00a0mg\/kg BID) or placebo (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a015) for 28 days. During storms, owners rated their dog's intensity for 16 behaviours using a Likert scale. Weekly, owners rated intensity and frequency of these behaviours. Summary scores were compared to baseline and between groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results and Conclusions<\/jats:bold>\n                    : Imepitoin was significantly superior to placebo in storm logs and weekly surveys for weeks 2 and 4, and in the end\u2010of\u2010study survey. Mild\/moderate adverse events were reported in 26 patients (24 active: two placebo); the most frequent adverse event was ataxia. Owners of dogs in the imepitoin group, compared to placebo, were significantly more likely to report that treatment reduced their dogs fear and anxiety during storms (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and other noise events (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Twice daily administration of imepitoin decreased anxiety scores in dogs with storm anxiety. Future work may evaluate optimal dosage regimens.\n                  <\/jats:p>","DOI":"10.1002\/vetr.18","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T14:06:22Z","timestamp":1611237982000},"source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of Pexion\n                    <sup>\u00ae<\/sup>\n                    (imepitoin) for treatment of storm anxiety in dogs: A randomised, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"188","author":[{"given":"Irina","family":"Perdew","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences North Carolina State University College of Veterinary Medicine  Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie","family":"Emke","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences North Carolina State University College of Veterinary Medicine  Raleigh North Carolina 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