{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:15:55Z","timestamp":1790198155387,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Since 2018, atrophy of the bursa has been found among vaccinated chickens with high antibody titres against infectious bursal disease virus (IBDV) in Fujian, China, suggesting poor vaccine efficacy against circulating IBDV strains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Novel IBDV strains were isolated, and\n                      <jats:italic>vp2<\/jats:italic>\n                      and\n                      <jats:italic>vp1<\/jats:italic>\n                      genes were sequenced and used to carry out phylogenetic analysis. Pathogenicity was investigated using 21\u2010day\u2010old specific pathogen\u2010free (SPF) chickens. In addition, the effectiveness of current commercial vaccines used in China was evaluated against the isolated novel IBDV strains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six IBDV isolates were successfully obtained, which formed an independent cluster and belonged to genotype A2dB1, based on phylogenetic analysis of the\n                      <jats:italic>vp2<\/jats:italic>\n                      and\n                      <jats:italic>vp1<\/jats:italic>\n                      genes. The pathogenicity of the novel IBDV FJ2019\u201001 isolate in 21\u2010day\u2010old SPF chickens was characterised by severe atrophy of the bursa and a largely decreased number of lymphocytes, atrophy of the follicle and broadening of mesenchyme in the bursa 3\u201323 days after infection. Unfortunately, all vaccinated chickens with high antibody titres against IBDV also developed atrophy and largely decreased lymphocytes in the bursa, as in the unvaccinated birds challenged with FJ2019\u201001. Furthermore, high viral loads of FJ2019\u201001 were detected in the bursa of all vaccinated chickens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that current commercial IBDV vaccines used in China did not provide protection against novel IBDV variants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.1840","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T02:33:51Z","timestamp":1662604431000},"source":"Crossref","is-referenced-by-count":31,"title":["Commercial vaccines used in China do not protect against a novel infectious bursal disease virus variant isolated in Fujian"],"prefix":"10.1002","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6575-3842","authenticated-orcid":false,"given":"Bo","family":"Hou","sequence":"first","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine Fujian Academy of Agricultural Sciences\/Fujian Animal Disease Control Technology Development Center  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine Fujian Academy of Agricultural Sciences\/Fujian Animal Disease Control Technology Development Center  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong\u2010Bao","family":"Luo","sequence":"additional","affiliation":[{"name":"Fujian Sunner Development Co.  Nanping Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Qing","family":"Shao","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine Fujian Academy of Agricultural Sciences\/Fujian Animal Disease Control Technology Development Center  Fuzhou Fujian China"},{"name":"Institute of Veterinary Medicine Jiangsu Academy of Agricultural Sciences\/National Research Center for Engineering and Technology of Veterinary Bio\u2010products  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"185","volume-title":"Diseases of poultry","author":"Eterradossi N","year":"2017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01501-07"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2020.108663"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00585-06"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079458008418423"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2003.08.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079457.2018.1506092"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079450400003650"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1637\/8455-082208-Reg.1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1637\/8957-061109-Reg.1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079459108418748"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2016.11.022"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.10.094"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079457.2012.661403"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2019.01.023"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msw054"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-019-00082-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079457.2021.1873245"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13091682"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.759861"},{"key":"e_1_2_10_22_1","unstructured":"Committee of Chinese Veterinary Pharmacopoeia.Veterinary Pharmacopoeia of the People's Republic of China (Three sections): 2015 edition. 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