{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:00:55Z","timestamp":1785538855502,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2022,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The treatment of canine adrenal insufficiency consists of hormone substitution and requires high owner compliance and intense human\u2013dog interaction. This might affect the quality of life (QoL) of owners and their pets. The aim of the study was to evaluate the impact of hypoadrenocorticism and its treatment on the QoL of dogs and their owners.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Owners completed a web\u2010based survey that contained items concerning signalment, owner QoL, dog QoL and long\u2010term therapy.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Three hundred and twenty\u2010two owners participated. Most owners feared an adrenal crisis. Approximately half of the participants reported that the bond between them and their pet increased after diagnosis. Although many participants felt that their own QoL was not affected by their dog's disease, worries about costs and leaving their dog unsupervised were frequently reported. Half of the study participants increased their dog's glucocorticoid doses when a stressful situation was foreseeable (\u2018boosting\u2019 of therapy). Some administered hydrocortisone, mostly switched from prednisolone, resulting in a reduction in side effects.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Special attention should be given to glucocorticoid therapy and owner's QoL. The overall worry of an adrenal crisis might increase caregivers\u2019 burden, reducing their overall QoL. Hydrocortisone might be a safe alternative to prednisolone, but further research is necessary to evaluate its long\u2010term efficacy and safety in dogs.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/vetr.1977","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:53:46Z","timestamp":1660006426000},"source":"Crossref","is-referenced-by-count":10,"title":["Effect of long\u2010term management of hypoadrenocorticism on the quality of life of affected dogs and their owners"],"prefix":"10.1002","volume":"191","author":[{"given":"Julia","family":"Hupfeld","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery University of Veterinary Medicine Hannover Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"D\u00f6lle","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover 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