{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:14:13Z","timestamp":1790615653424,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      A cross\u2010species jump was confirmed in 2018, when a novel recombinant myxoma virus (MYXV) (ha\u2010MYXV) caused high mortality in Iberian hare (\n                      <jats:italic>Lepus granatensis<\/jats:italic>\n                      ) in the Iberian Peninsula.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the main lesions, tissular distribution and target cells of ha\u2010MYXV in Iberian hare. Gross postmortem examinations and histological and immunohistochemical studies to detect ha\u2010MYXV were carried out in 28 animals that were confirmed as ha\u2010MYXV positive by PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The main macroscopic lesions were bilateral blepharoconjunctivitis, epistaxis, intense congestion and oedema in several organs and some internal haemorrhages. Visible myxomas were not found. Histopathological examination revealed hyperplastic epidermis with predominant hyperkeratosis and myxoid matrix in the dermis. ha\u2010MYXV\u2010positive keratinocytes showed hydropic degeneration and cytoplasmic inclusion bodies. Alveolar oedema, interstitial pneumonia, dramatic lymphoid depletion in the spleen and necrosis in the liver and testis were observed. ha\u2010MYXV was mainly detected in epithelial and myxoma cells in\u00a0the skin, and also in macrophages, lymphocytes, fibroblasts and endothelial cells in several organs, as well as in hepatocytes and Leydig cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>A non\u2010homogeneous number of samples were included in all the animals. Future experimental studies with controlled variables are necessary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings correspond to an unusual form of myxomatosis, characterised by an acute or hyperacute presentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.2182","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T09:59:03Z","timestamp":1663754343000},"source":"Crossref","is-referenced-by-count":6,"title":["Pathological changes and viral antigen distribution in tissues of Iberian hare (\n                    <i>Lepus granatensis<\/i>\n                    ) naturally infected with the emerging recombinant myxoma virus (ha\u2010MYXV)"],"prefix":"10.1002","volume":"192","author":[{"given":"Irene","family":"Agull\u00f3\u2010Ros","sequence":"first","affiliation":[{"name":"Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda, Grupo de Investigaci\u00f3n GISAZ, UIC Zoonosis y Enfermedades Emergentes ENZOEM Universidad de C\u00f3rdoba  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Jim\u00e9nez\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Sanidad Animal, Grupo de Investigaci\u00f3n GISAZ, UIC Zoonosis y Enfermedades Emergentes ENZOEM Universidad de C\u00f3rdoba  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Camacho\u2010Sillero","sequence":"additional","affiliation":[{"name":"Programa Vigilancia Epidemiol\u00f3gica Fauna Silvestre (PVE), Consejer\u00eda Agricultura, Ganader\u00eda, Pesca y Desarrollo Sostenible Junta de Andaluc\u00eda  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0012-4006","authenticated-orcid":false,"given":"Christian","family":"Gort\u00e1zar","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Recursos Cineg\u00e9ticos (IREC) CSIC\u2010UCLM\u2010JCCM  Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Capucci","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cano\u2010Terriza","sequence":"additional","affiliation":[{"name":"Departamento de Sanidad Animal, Grupo de Investigaci\u00f3n GISAZ, UIC Zoonosis y Enfermedades Emergentes ENZOEM Universidad de C\u00f3rdoba  C\u00f3rdoba Spain"},{"name":"CIBERINFEC, ISCIII\u2014CIBER de Enfermedades Infecciosas Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Zorrilla","sequence":"additional","affiliation":[{"name":"Centro de An\u00e1lisis y Diagn\u00f3stico de la Fauna Silvestre en Andaluc\u00eda, Agencia de Medio, Ambiente y Agua M.P. Junta de Andaluc\u00eda  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"G\u00f3mez\u2010Guillam\u00f3n","sequence":"additional","affiliation":[{"name":"Programa Vigilancia Epidemiol\u00f3gica Fauna Silvestre (PVE), Consejer\u00eda Agricultura, Ganader\u00eda, Pesca y Desarrollo Sostenible Junta de Andaluc\u00eda  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3388-2604","authenticated-orcid":false,"given":"Ignacio","family":"Garc\u00eda\u2010Bocanegra","sequence":"additional","affiliation":[{"name":"Departamento de Sanidad Animal, Grupo de Investigaci\u00f3n GISAZ, UIC Zoonosis y Enfermedades Emergentes ENZOEM Universidad de C\u00f3rdoba  C\u00f3rdoba Spain"},{"name":"CIBERINFEC, ISCIII\u2014CIBER de Enfermedades Infecciosas Instituto de Salud Carlos III  Madrid Spain"},{"name":"Unidad de Enfermedades Infecciosas, Grupo de Virolog\u00eda Cl\u00ednica y Zoonosis, Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC) Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A.","family":"Risalde","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda, Grupo de Investigaci\u00f3n GISAZ, UIC Zoonosis y Enfermedades Emergentes ENZOEM Universidad de C\u00f3rdoba  C\u00f3rdoba Spain"},{"name":"CIBERINFEC, ISCIII\u2014CIBER de Enfermedades Infecciosas Instituto de Salud Carlos III  Madrid Spain"},{"name":"Unidad de Enfermedades Infecciosas, Grupo de Virolog\u00eda Cl\u00ednica y Zoonosis, Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC) Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx932"},{"key":"e_1_2_10_3_1","first-page":"865","article-title":"Das myxomatogene Virus. Beitrag zum Studium der Krankheitserreger ausserhalb des Sichtbaren","volume":"23","author":"Sanarelli B","year":"1898","journal-title":"Zentralbl Bakteriol Parasitenkd Infektionskrh."},{"issue":"2","key":"e_1_2_10_4_1","first-page":"549","volume":"34","author":"Bertagnoli S","year":"2015","journal-title":"Myxomatosis. Rev Sci Tech."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1556\/avet.51.2003.4.7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-42-76"},{"key":"e_1_2_10_7_1","unstructured":"OIE.Manual of diagnostic tests and vaccines for terrestrial animals. Chapter 3.6.1. Paris France: World Organization for Animal Health; 2018. Available from:https:\/\/www.oie.int\/fileadmin\/Home\/esp\/Health_standards\/tahm\/3.06.01_Mixomatosis.pdf"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/v7031020"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4995\/wrs.2019.10585"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.g4621"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11060530"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.13289"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.13781"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/vetreccr-2019-001044"},{"key":"e_1_2_10_15_1","unstructured":"OIE.World animal health information system.2022. Available from:https:\/\/wahis.oie.int\/#\/home"},{"key":"e_1_2_10_16_1","unstructured":"DuarteMD CarvalhoCL dos SantosFA MonteiroJ MonteiroM CarvalhoPM et\u00a0al. The health and future of the six hare species in Europe: a closer look at the Iberian hare. IntechOpen;2020."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.06.017"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2013.11.014"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.13296"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(95)00033-M"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12101127"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.13899"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau7285"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2013.02.002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2016.09.019"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2006054"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.1999.0335"},{"key":"e_1_2_10_28_1","first-page":"268","article-title":"Myxomatosis in the common hare","volume":"9","author":"Collins JJ","year":"1955","journal-title":"Ir Vet J."},{"key":"e_1_2_10_29_1","first-page":"105","article-title":"Sur un cas de myxomatose chez le lievre","volume":"86","author":"Jacotot H","year":"1954","journal-title":"Ann del'Institut Pasteur"},{"key":"e_1_2_10_30_1","first-page":"267","article-title":"Myxomatosis in the common hare","volume":"9","author":"Whitty BT","year":"1955","journal-title":"Ir Vet J."},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0505"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.j4450"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.09.031"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.1999.0345"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710336114"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1940.tb01490.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.12.007"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0003"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1100161"},{"key":"e_1_2_10_40_1","unstructured":"CastelliniC CenciT ScuotaS LattaioliP BattagliniM.La myxomatose: implications possibles sur la pratique de l'ins\u00e9mination artificielle.Proc. 6 \u00e8mes Journees de la Recherche Cunicole La Rochelle France.1994;9\u201317."},{"key":"e_1_2_10_41_1","article-title":"Histology, Leydig cells","author":"Aladamat N","year":"2021","journal-title":"StatPearls"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.02.012"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.2182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vetr.2182","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.2182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:29:25Z","timestamp":1761568165000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1002\/vetr.2182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,21]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/vetr.2182"],"URL":"https:\/\/doi.org\/10.1002\/vetr.2182","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,21]]},"article-number":"e2182"}}