{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:34:54Z","timestamp":1761561294342,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum fructosamine (sFA) is used to assess glycaemic control in dogs with diabetes mellitus (DM). Nevertheless, its interpretation is hindered by several limitations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study evaluates the long\u2010term diagnostic performance of sFA for monitoring\u00a0clinical control of DM. sFA, bodyweight, appetite, presence of polyuria\/polydipsia and clinical scores (CS; well\u2010controlled DM, CS\u20100; uncontrolled DM, CS\u20101) were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 75 dogs (321 visits; median 3 visits\/dog; range 1\u201319). Mean sFA was higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) on visits with CS\u20101 (584\u00a0\u03bcmol\/L; 95% confidence interval [95% CI] 561\u2013608) than on visits with CS\u20100 (506\u00a0\u03bcmol\/L; 95% CI 484\u2013528). Increases in sFA increased \u00a0 the odds ratio for CS\u20101 (1.37; 95% CI 1.24\u20131.52,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). sFA was moderately predictive of the CS (area under receiver operating characteristic curve = 0.75; 95% CI 0.70\u20130.80;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), with a 486\u00a0\u03bcmol\/L cutoff yielding 80% sensitivity and 59% specificity. Mean sFA was lower (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005) when hypoglycaemic episodes were suspected (496\u00a0\u03bcmol\/L; 95% CI 450\u2013541) than in their absence (572\u00a0\u03bcmol\/L; 95% CI 548\u2013596). sFA is moderately accurate for classifying CS in diabetic dogs. Decreasing sFA over follow\u2010ups indicates improved CS but might suggest occurrence of hypoglycaemic episodes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Retrospective design, variable treatments and comorbidities are limitations of this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>sFA has a moderate clinical utility in the long\u2010term monitoring of diabetic dogs, but may serve as a first\u2010line, accessible diagnostic tool. Discordant CS and sFA evaluation, or decreased sFA, warrants additional monitoring (i.e., continuous glucose monitoring).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.2236","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T23:18:35Z","timestamp":1664579915000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical utility of serum fructosamine in long\u2010term monitoring of diabetes mellitus in dogs"],"prefix":"10.1002","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7130-1706","authenticated-orcid":false,"given":"Sharon","family":"Kuzi","sequence":"first","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6193-5817","authenticated-orcid":false,"given":"Michal","family":"Mazaki\u2010Tovi","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiessam Abu","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Ovadia","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itamar","family":"Aroch","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6822"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb03183.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.81.3.233"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01839201"},{"key":"e_1_2_11_6_1","first-page":"193","volume-title":"editors. 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