{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:03:26Z","timestamp":1777935806518,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a lack of consensus regarding which markers of disease resolution to prioritise when assessing treatment response in client\u2010owned dogs with aspiration\u2010induced lung injury. This study describes the change over time and the agreement between the clinical markers used to determine disease resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Physical examination (PE), owner\u2010reported clinical signs (CS\u2010O), thoracic radiographs (TXR) scores and C\u2010reactive protein (CRP) concentrations were determined at enrolment, after 24, 48 and 72 hours, and after 7, 14 and 28 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PE scores were significantly improved at 48 hours, while CRP initially increased (24 hours) and then decreased (48 hours). PE, CS\u2010O and CRP significantly improved earlier (7 days) than TXR (14 days). The median number of days to marker normalisation was 7, 9 and 14 for PE, CRP and CS\u2010O, respectively. Marker agreement was excellent\/very good at enrolment and fair\/poor during disease recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Analysis did not control for differences aetiology of aspiration or the lack of standardisation in treatment approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PE was the earliest and most consistent marker indicating disease resolution. Serial CRP monitoring (72 hours) may provide an objective marker of early treatment response. Alongside PE normalisation, improvement in CS\u2010O, CRP and TRX may assist in determining disease resolution and guide treatments, including limiting antibiotic exposure in dogs with aspiration\u2010induced lung injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.2280","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T11:20:36Z","timestamp":1666005636000},"source":"Crossref","is-referenced-by-count":2,"title":["Change over time and agreement between clinical markers of disease resolution in dogs with aspiration\u2010induced lung injury"],"prefix":"10.1002","volume":"192","author":[{"given":"Monica","family":"Chwala","sequence":"first","affiliation":[{"name":"BluePearl Pet Hospital  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faye","family":"Hartmann","sequence":"additional","affiliation":[{"name":"UW Veterinary Care University of Wisconsin\u2010Madison  Madison Wisconsin 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