{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:20:21Z","timestamp":1782588021588,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:00:00Z","timestamp":1670716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Concurrent osteoarthritis is generally present in the stifle joints of dogs with cranial cruciate ligament disease (CCLD), but it is not known if the degree of osteoarthritis\u2010related changes affects the prognosis. Development of osteophytes is a key radiographic feature of osteoarthritis. The aim of this study was to evaluate the association between the degree of osteophyte formation seen on radiographs and CCLD\u2010related euthanasia in dogs with CCLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study including 226 dogs treated for CCLD at two university animal hospitals was performed. Clinical and follow\u2010up information was retrieved, and stifle radiographs taken during the 31 days before treatment for the CCLD were graded for osteophyte formation by three veterinary radiologists. A multivariable Cox proportional hazards model was applied to assess the association between the degree of osteophyte formation and CCLD\u2010related euthanasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An association between the degree of osteophyte formation and CCLD\u2010related euthanasia was found, with increased osteophyte formation associated with an increased hazard of CCLD\u2010related euthanasia (hazard ratio 1.06, 95% confidence interval 1.01\u20131.11,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>No clinical assessment of the outcome was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings suggest that evaluation of stifle radiographs for osteophyte formation could provide useful prognostic information for dogs with CCLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.2478","type":"journal-article","created":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T22:47:07Z","timestamp":1670798827000},"source":"Crossref","is-referenced-by-count":3,"title":["Degree of osteophyte formation seen on radiographs provides useful prognostic information for dogs with cruciate ligament disease"],"prefix":"10.1002","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2800-9990","authenticated-orcid":false,"given":"Karolina","family":"Engdahl","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6889-4002","authenticated-orcid":false,"given":"Gudrun Seeberg","family":"Boge","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences Norwegian University of Life Sciences\u2014School of Veterinary Science  Oslo Norway"},{"name":"Norwegian Medicines Agency  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4325-5743","authenticated-orcid":false,"given":"Jessica","family":"Ingman","sequence":"additional","affiliation":[{"name":"University Animal Hospital Swedish University of Agricultural Sciences  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0171-6858","authenticated-orcid":false,"given":"Veronica","family":"N\u00e4slund","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3707-6602","authenticated-orcid":false,"given":"Charles J","family":"Ley","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences  Uppsala 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