{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:26:12Z","timestamp":1762431972138,"version":"build-2065373602"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : We aimed to identify prognostic markers and their discriminant score in predicting the lethal outcome of canine\n                    <jats:italic>Babesia gibsoni<\/jats:italic>\n                    .\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : Blood samples were collected from 108 client\u2010owned dogs with clinical signs commensurate with babesiosis to analyze haematological, biochemical, haemostatic, antioxidant profile and thiobarbituric acid reactive substance levels. Samples were screened for\n                    <jats:italic>Babesia<\/jats:italic>\n                    infection (microscopic and molecular techniques). Babesiosis\u2010affected dogs were classified into survivors and non\u2010survivors, and 30 healthy dogs were used in the control group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Haemoglobin, thrombocytes, catalase, urea, creatinine, alanine aminotransferase (ALT), alkaline phosphatase, lactate and reticulocytes were highly correlated to survival. Receiver operating characteristics analysis revealed urea, ALT and lactate as specific prognostic markers for the disease. The formula for calculation of discriminant scores (Di) for lethal outcome of the disease was generated with cut\u2010off score 0.141. The scoring system was 79% sensitive and 83% specific in predicting the lethal outcome of the disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : A scoring system developed from the prognosticating markers may aid in predicting the outcome of\n                    <jats:italic>Babesia gibsoni<\/jats:italic>\n                    infection on the day of presentation itself enabling intensive care for those animals with a cut\u2010off score more than 0.141.\n                  <\/jats:p>","DOI":"10.1002\/vetr.29","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T14:06:50Z","timestamp":1611238010000},"source":"Crossref","is-referenced-by-count":2,"title":["Prognostic markers and their discriminant score in predicting the outcome of\n                    <i>Babesia gibsoni<\/i>\n                    infection"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5462-3121","authenticated-orcid":false,"given":"Rajamanickam","family":"Kandasamy","sequence":"first","affiliation":[{"name":"Department of Veterinary Physiology Madras Veterinary College, TANUVAS  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leela","family":"Venkatasubramanian","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology Madras Veterinary College, TANUVAS  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karuppusamy","family":"Loganathasamy","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry Veterinary College and Research Institute  Tirunelveli India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaskaran Ravi","family":"Latha","sequence":"additional","affiliation":[{"name":"Department of Veterinary Parasitology Madras 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