{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:28:54Z","timestamp":1775284134423,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2023,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The contrast\u2010enhanced ultrasound (CEUS) features of adrenal lesions are poorly reported in veterinary literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Qualitative and quantitative B\u2010mode ultrasound and CEUS features of 186 benign (adenoma) and malignant (adenocarcinoma and pheochromocytoma) adrenal lesions were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Adenocarcinomas (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a072) and pheochromocytomas (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a032) had mixed echogenicity with B\u2010mode, and a non\u2010homogeneous aspect with a diffused or peripheral enhancement pattern, hypoperfused areas, intralesional microcirculation and non\u2010homogeneous wash\u2010out with CEUS. Adenomas (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a082) had mixed echogenicity, isoechogenicity or hypoechogenicity with B\u2010mode, and a homogeneous or non\u2010homogeneous aspect with a diffused enhancement pattern, hypoperfused areas, intralesional microcirculation and homogeneous wash\u2010out with CEUS. With CEUS, a non\u2010homogeneous aspect and the presence of hypoperfused areas and intralesional microcirculation can be used to distinguish\u00a0between malignant (adenocarcinoma and pheochromocytoma) and benign (adenoma) adrenal lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Lesions were characterised only by means of cytology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CEUS examination is a valuable tool for distinction between benign and malignant adrenal lesions and can potentially differentiate pheochromocytomas from adenocarcinomas and adenomas. However, cytology and histology are necessary to obtain the final diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.2949","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T01:40:56Z","timestamp":1683164456000},"source":"Crossref","is-referenced-by-count":6,"title":["Contrast\u2010enhanced ultrasound features of adrenal lesions in dogs"],"prefix":"10.1002","volume":"193","author":[{"given":"Silvia","family":"Burti","sequence":"first","affiliation":[{"name":"Department of Animal Medicine Production and Health University of Padua  Legnaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Zotti","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine Production and Health University of Padua  Legnaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Rubini","sequence":"additional","affiliation":[{"name":"ULTRAVET San Giovanni 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