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Cats with CDS display behavioural abnormalities, including excessive Vocalisation, altered Interaction with owners (increased affection\/attention), altered Sleep\u2010wake cycles, House\u2010soiling, Disorientation (spatial and\/or temporal), alterations in Activity, Anxiety, and\/or Learning\/memory deficits (i.e., VISHDAAL). These cats develop neuropathologies, such as accumulation of\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010amyloid and hyperphosphorylated tau deposits. Because of its similarities to those in the brains of people with cognitive impairment and AD, the domestic cat could be a natural model for human dementia studies. It is important to diagnose CDS promptly in cats, ruling out other causes for these behavioural changes, to provide effective management. Interventions include environmental enrichment (e.g., easy access to key resources, calming pheromones), dietary supplementations (e.g., Senilife, Aktivait for cats, SAMe), specific diets (e.g., containing antioxidants, medium\u2010chain triglycerides) and, potentially, medication (e.g., selegiline or propentofylline). This article reviews the literature about CDS in cats, its causes, neuropathology, clinical signs, diagnosis and potential management options. By doing so, it furthers our understanding of this condition and allows improved health, welfare and quality of life of affected cats.\n                  <\/jats:p>","DOI":"10.1002\/vetr.3","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T03:32:46Z","timestamp":1610681566000},"source":"Crossref","is-referenced-by-count":57,"title":["Cognitive Dysfunction in Cats: Update on Neuropathological and Behavioural Changes Plus Clinical Management"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-6706","authenticated-orcid":false,"given":"Lorena","family":"Sordo","sequence":"first","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies and The Roslin Institute The University of Edinburgh  Easter Bush Campus Roslin UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00e8lle A.","family":"Gunn\u2010Moore","sequence":"additional","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies and The Roslin Institute The University of Edinburgh  Easter Bush Campus Roslin UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14536176"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.5326\/0460070"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2014.07.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(83)90053-2"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(87)90010-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(82)90036-7"},{"key":"e_1_2_12_8_1","unstructured":"LandsbergGM. 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