{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:53:27Z","timestamp":1789386807142,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T00:00:00Z","timestamp":1685750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2023,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Streptococcus suis<\/jats:italic>\n                      can cause meningitis, polyarthritis and acute death in piglets. However, the risk factors associated with\n                      <jats:italic>S. suis<\/jats:italic>\n                      infection remain incompletely understood. Therefore, a longitudinal study was carried out, in which six batches from two Spanish pig farms with\n                      <jats:italic>S. suis<\/jats:italic>\n                      problems were repeatedly examined to determine possible risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective case\u2013control study was conducted, and potential risk factors were evaluated using mixed\u2010effects logistic regression models. The explanatory variables included: (a) concomitant pathogens; (b) biomarkers associated with stress, inflammation and oxidative status; (c) farm environmental factors; and (d) parity and\n                      <jats:italic>S. suis<\/jats:italic>\n                      presence in sows. Three models were built to study the effect of these variables, including two to assess the risk factors involved in the subsequent development of disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Risk factors for\n                      <jats:italic>S. suis<\/jats:italic>\n                      \u2010associated disease included porcine reproductive and respiratory syndrome virus co\u2010infection at weaning (odds ratio [OR] = 6.69), sow parity (OR = 0.71), haptoglobin level before weaning (OR = 1.01), relative humidity (OR = 1.11) and temperature (OR = 0.13).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Laboratory diagnosis was done at the batch level, with individual diagnosis based on clinical signs only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study confirms the multifactorial nature of\n                      <jats:italic>S. suis<\/jats:italic>\n                      \u2010associated disease, with both environmental factors and factors related to the host involved in disease development. Controlling these factors may, therefore, help prevent the appearance of disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.3056","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T14:33:52Z","timestamp":1685802832000},"source":"Crossref","is-referenced-by-count":14,"title":["Risk factors associated with\n                    <i>Streptococcus suis<\/i>\n                    cases on pig farms in Spain"],"prefix":"10.1002","volume":"193","author":[{"given":"Carlos","family":"Neila\u2010Ib\u00e1\u00f1ez","sequence":"first","affiliation":[{"name":"Unitat mixta d'Investigaci\u00f3 IRTA\u2010UAB en Sanitat Animal Centre de Recerca en Sanitat Animal, Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"},{"name":"Institut de Recerca i Tecnologia Agroaliment\u00e0ries Centre de Recerca en Sanitat Animal, Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"},{"name":"OIE Collaborating Centre for the Research 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