{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:55:20Z","timestamp":1792418120124,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2023,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to investigate the effects of gabapentin on various ocular parameters in New Zealand White rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomised, placebo\u2010controlled crossover study design was employed. Eight New Zealand White rabbits were randomly assigned to receive either oral gabapentin at a dosage of 15\u00a0mg\/kg or an oral placebo, with a 1\u2010week washout period between treatments. Intraocular pressure, tear production and horizontal pupil diameter were measured at baseline (T0) and at 30, 60, 90, 120, 180, 240 and 360 minutes after drug administration. Physiological and behavioural changes were also recorded for both treatments following drug administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The administration of gabapentin did not have any significant effects on the ocular parameters measured in this study. However, the rabbits exhibited some muscle relaxation with partially closed eyes during handling, and they were slightly easier to remove from the cage when treated with gabapentin compared to the placebo treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>In this study, the ocular effects of gabapentin were assessed in only a small number of healthy rabbits. These effects may differ in rabbits with pre\u2010existing eye conditions or in those receiving other medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that gabapentin treatment does not have a significant impact on intraocular pressure, tear production or horizontal pupil diameter in rabbits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.3558","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T05:06:39Z","timestamp":1698383199000},"source":"Crossref","is-referenced-by-count":5,"title":["Effects of gabapentin on intraocular pressure, tear production and horizontal pupil diameter in New Zealand White rabbits"],"prefix":"10.1002","volume":"193","author":[{"given":"Harun","family":"Cinar","sequence":"first","affiliation":[{"name":"Department of Surgery Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latif E.","family":"Yanmaz","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Isil","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim T.","family":"Danisman","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118910337.ch6"},{"key":"e_1_2_10_3_1","first-page":"533","volume-title":"Veterinary ophthalmology","author":"Featherstone HJ","year":"2013"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X18787910"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcam.2023.100779"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.251.10.1175"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X17719399"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.21.03.0167"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/vetr.453"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2008.06.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jepm.2023.02.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01627.x"},{"key":"e_1_2_10_13_1","first-page":"1","article-title":"Effect of two different doses of gabapentin on the intraocular pressure and hemodynamic stress responses to laryngoscopy and tracheal intubation","volume":"2013","author":"Ali AA","year":"2013","journal-title":"Int Sch Res Notices"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302937"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-019-01156-w"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.81.12.973"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.13018"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-380920-9.00010-9"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1206-1"},{"key":"e_1_2_10_20_1","unstructured":"RajotteS SalpeterEM MartinsBC Smith FlemingKM.Effect of gabapentin on ocular parameters following oral administration in healthy dogs. In: Proceedings of the50th Annual Conference of the American College of Veterinary Ophthalmologists Maui HI 6\u20139 November2019."},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14639"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.21615\/cesmvz.6319"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-022-03492-1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.applanim.2019.104875"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.3558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T06:50:22Z","timestamp":1761634222000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1002\/vetr.3558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,27]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,12,2]]}},"alternative-id":["10.1002\/vetr.3558"],"URL":"https:\/\/doi.org\/10.1002\/vetr.3558","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,27]]},"article-number":"e3558"}}