{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:58:08Z","timestamp":1786978688026,"version":"build-2736575974"},"reference-count":76,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of this study was to analyse the potential benefit of the epidural application of steroids on time to ambulation in non\u2010ambulatory dogs affected by intervertebral disc disease (IVDD) treated with decompressive surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective, randomised, blinded control trial involved 41 dogs with thoracolumbar disc extrusion, which were randomly allocated into two groups. In the control group, saline was locally applied after surgical decompression of the spinal cord (\n                      <jats:italic>n<\/jats:italic>\n                      = 23). In the treatment group (\n                      <jats:italic>n<\/jats:italic>\n                      = 18), local epidural application of methylprednisolone acetate (1\u00a0mg\/kg) was used. Ambulation time was the primary outcome measure, defined as the ability to take 10 independent steps.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median number of days to ambulation was 7 days (range: 1\u201217 days) for the control group and 3 days (range: 1\u20128 days) for the treatment group. One dog from the treatment group developed discospondylitis and abscess formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>The study's heterogeneity in dog breeds, ages and pre\u2010existing health conditions could affect the generalisability of the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Epidural methylprednisolone acetate applied locally at the time of surgery may accelerate recovery in dogs following IVDD surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.4962","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T06:45:07Z","timestamp":1735281907000},"source":"Crossref","is-referenced-by-count":4,"title":["Effect of local epidural application of methylprednisolone acetate on time to ambulation in non\u2010ambulatory dogs with thoracolumbar intervertebral disc disease: A prospective randomised, blinded control trial"],"prefix":"10.1002","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8122-8899","authenticated-orcid":false,"given":"Pavlos","family":"Natsios","sequence":"first","affiliation":[{"name":"Small Animal Surgery Clinic Vetsuisse Faculty University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Golini","sequence":"additional","affiliation":[{"name":"Division of Neurology Vetsuisse Faculty University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian H.","family":"Park","sequence":"additional","affiliation":[{"name":"Small Animal Surgery Clinic Vetsuisse Faculty University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Steffen","sequence":"additional","affiliation":[{"name":"Division of Neurology Vetsuisse Faculty University of Zurich Zurich 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