{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T18:53:03Z","timestamp":1764442383415,"version":"3.46.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010712","name":"Agricultural and Horticultural Development Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2025,11,15]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n \n Joint\u2010ill in neonatal lambs, primarily caused by\n Streptococcus dysgalactiae<\/jats:italic>\n subspecies\n dysgalactiae<\/jats:italic>\n (SDSD),\u00a0results in increased mortality and morbidity. An effective vaccine is needed to prevent the disease.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A blinded randomised controlled trial was carried out using an autologous SDSD vaccine in a commercial sheep flock in the UK. Two doses of vaccine were administered to 481 pregnant ewes, with 509 ewes left unvaccinated. The SDSD antibody titres of the ewes and their lambs were then measured. Any adverse effects or cases of joint\u2010ill were also reported.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Ten cases of joint\u2010ill occurred, with five of these lambs born to vaccinated ewes and five to unvaccinated ewes. Serum from 85 vaccinated ewes and 88 control ewes was analysed using an SDSD antibody ELISA, with higher titres found in vaccinated ewes. Higher SDSD titres were observed in lambs from vaccinated ewes (\n n<\/jats:italic>\n = 87) than in lambs from unvaccinated ewes (\n n<\/jats:italic>\n = 91). No differences were detected between colostrum samples from vaccinated and unvaccinated ewes. No vaccination\u2010associated adverse effects were detected.\n <\/jats:p>\n <\/jats:sec>\n \n Limitations<\/jats:title>\n Randomisation was effective; however, ELISA data were limited to mainly crossbred ewes, reducing the power of the breed comparisons.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The vaccine had no effect in reducing the number of lambs with joint\u2010ill\u00a0born to vaccinated ewes compared with unvaccinated ewes. However, vaccinating ewes did have a positive effect on their serum SDSD antibody concentrations and those of their lambs.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/vetr.5667","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:18:11Z","timestamp":1760105891000},"source":"Crossref","is-referenced-by-count":0,"title":["Randomised controlled field trial to assess the safety and efficacy of a killed autologous vaccine against\n Streptococcus dysgalactiae<\/i>\n subspecies\n dysgalactiae<\/i>\n in a sheep flock"],"prefix":"10.1002","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3684-0277","authenticated-orcid":false,"given":"Joseph W.","family":"Angell","sequence":"first","affiliation":[{"name":"Department of Research and Innovation Wern Vets Ruthin UK"},{"name":"Department of Livestock and One Health Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naseem","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Livestock and One Health Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise P.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Livestock and One Health Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantina","family":"Kasiora","sequence":"additional","affiliation":[{"name":"Department of Livestock and One Health Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Ballingall","sequence":"additional","affiliation":[{"name":"Moredun Research Institute Penicuik UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1370-3085","authenticated-orcid":false,"given":"Jennifer S.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Livestock and One Health Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(98)80132-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2019.06.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2008.06.001"},{"key":"e_1_2_11_5_1","first-page":"833","article-title":"Joint\u2010ill in lambs","volume":"5","author":"Cornell RL","year":"1925","journal-title":"Vet Rec."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102781"},{"key":"e_1_2_11_7_1","unstructured":"European Medicines Agency. EMA categorisation of antibiotics in the European Union.2019.www.ema.europa.eu\/en\/documents\/report\/categorisation\u2010antibiotics\u2010european\u2010union\u2010answer\u2010request\u2010european\u2010commission\u2010updating\u2010scientific_en.pdf"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2024.1489751"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101753"},{"key":"e_1_2_11_10_1","unstructured":"JacksonLP.Preventing neonatal infectious arthritis in lambs: sources transmission and characterisation ofStreptococcus dysgalactiae. PhD Thesis.Department of Livestock and One Health of the Institute of Infection Veterinary and Ecological Sciences University of Liverpool;2024."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2021.109221"},{"key":"e_1_2_11_12_1","first-page":"1207","article-title":"Joint\u2010ill polyarthritis of lambs in East Anglia","volume":"51","author":"Blakemore F","year":"1939","journal-title":"Vet Rec."},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700520105"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2025.105604"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2019.104752"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.5667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T18:48:16Z","timestamp":1764442096000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1002\/vetr.5667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,11,15]]}},"alternative-id":["10.1002\/vetr.5667"],"URL":"https:\/\/doi.org\/10.1002\/vetr.5667","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"type":"print","value":"0042-4900"},{"type":"electronic","value":"2042-7670"}],"subject":[],"published":{"date-parts":[[2025,10,10]]}}}