{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:56:03Z","timestamp":1775480163998,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2026,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence regarding the diagnostic utility of serum anti\u2010desmoglein\u20102 (DSG2) autoantibodies for arrhythmogenic right ventricular cardiomyopathy (ARVC) in boxer dogs is conflicting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective standardised evaluation of apparently healthy boxer dogs for ARVC was performed at three referral centres, including blood pressure measurement, electrocardiography, echocardiography, haematology, biochemistry (including cardiac troponin I) and 24\u2010hour Holter monitoring. Additional dogs with a diagnosis of ARVC were retrospectively recruited. ARVC disease status was defined using cut\u2010offs of 20 or less (unaffected) and more than 300 (affected) ventricular premature complexes of right ventricular origin in 24 hours. The residual serum samples were stored at \u201280\u00b0C for analysis for anti\u2010DSG2 autoantibodies using ELISA techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty boxer dogs were enrolled (11 healthy controls, 10 with preclinical ARVC and 19 with clinical ARVC). Serum anti\u2010DSG2 autoantibodies were detected in all dogs, bar one healthy dog. DSG2 differed significantly between groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.031) and was significantly lower in dogs with preclinical versus clinical ARVC (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Some data were collected retrospectively, and some dogs were receiving antiarrhythmic therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum DSG2 autoantibodies can be present in boxer dogs with preclinical and clinical ARVC and apparently healthy controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.6014","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:38:26Z","timestamp":1765039106000},"source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010desmoglein\u20102 autoantibodies do not discriminate between UK boxer dogs with and without arrhythmogenic right ventricular cardiomyopathy"],"prefix":"10.1002","volume":"198","author":[{"given":"Chia\u2010Hsuan","family":"Chang","sequence":"first","affiliation":[{"name":"Bristol Veterinary School University of Bristol  Langford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Watson","sequence":"additional","affiliation":[{"name":"Langford Vets University of Bristol  Langford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diptendu","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Labatt Family Heart Centre, The Hospital for Sick Children &amp; Research Institute University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade","family":"Ward","sequence":"additional","affiliation":[{"name":"Bristol Veterinary School University of Bristol  Langford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9199-4941","authenticated-orcid":false,"given":"Kieran","family":"Borgeat","sequence":"additional","affiliation":[{"name":"Langford Vets University of Bristol  Langford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-8479","authenticated-orcid":false,"given":"Hannah","family":"Hodgkiss\u2010Geere","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0326-8251","authenticated-orcid":false,"given":"Joanna","family":"Dukes\u2010McEwan","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-1278","authenticated-orcid":false,"given":"Robert","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Labatt Family Heart Centre, The Hospital for Sick Children &amp; Research Institute University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1890-6161","authenticated-orcid":false,"given":"Melanie J.","family":"Hezzell","sequence":"additional","affiliation":[{"name":"Bristol Veterinary School University of Bristol  Langford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2021.07.001"},{"key":"e_1_2_11_3_1","first-page":"329","volume-title":"Current veterinary therapy VIII","author":"Harpster NK","year":"1983"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(91)50107-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2004.05.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.5.524"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy567"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-32081-x"},{"key":"e_1_2_11_9_1","volume-title":"Anti\u2010desmosomal antibody as a potential biomarker of arrhythmia burden in boxers with arrhythmogenic ventricular cardiomyopathy","author":"dos Santos L","year":"2022"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb02551.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0121.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12385"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2021.10.003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2023.05.018"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2010.06.005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.770"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0366.x"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.6014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vetr.6014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.6014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:09:31Z","timestamp":1775477371000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1002\/vetr.6014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,6]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,3,28]]}},"alternative-id":["10.1002\/vetr.6014"],"URL":"https:\/\/doi.org\/10.1002\/vetr.6014","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,6]]}}}