{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T22:52:41Z","timestamp":1769899961067,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2026,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study examined the relationship between anxiety and plasma hormonal concentration (thyroxin, canine thyroid\u2010stimulating hormone [cTSH] and prolactin) in male dogs, utilising the Evaluation of Dog's Emotional and cognitive Disorders (EDED) scale for anxiety assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This research included a control group of non\u2010anxious dogs for comparative purposes, with hormonal levels measured under controlled conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The findings showed no significant difference in thyroxin and cTSH concentrations between anxious and non\u2010anxious dogs, indicating that anxiety might not directly influence these hormones. However, a significant elevation in prolactin levels was observed in anxious dogs, suggesting its potential as a biomarker for anxiety\u2010related disorders in canines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>The study should be conducted on more dogs to confirm these results. Exploring prolactin concentration levels in females considering their estrous cycle should be performed in future research to be able to use prolactin as a biological marker of anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study contributes to the understanding of the neuroendocrine underpinnings of canine anxiety, proposing future research directions to explore the causal relationships between prolactin and anxiety and the therapeutic implications of modulating prolactin levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.6015","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T12:29:21Z","timestamp":1764851361000},"source":"Crossref","is-referenced-by-count":0,"title":["Prospective study of plasma prolactin and thyroxin concentrations in anxious and non\u2010anxious dogs"],"prefix":"10.1002","volume":"198","author":[{"given":"Fran\u00e7oise","family":"Schwobthaler","sequence":"first","affiliation":[{"name":"Atlantia Centre Hospitalier V\u00e9t\u00e9rinaire  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6089-5825","authenticated-orcid":false,"given":"Sylvia","family":"Masson","sequence":"additional","affiliation":[{"name":"Veterinary Behaviour Clinic  Voreppe France"},{"name":"No Ledge Research  Voreppe France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Bleuer\u2010Elsner","sequence":"additional","affiliation":[{"name":"No Ledge Research  Voreppe France"},{"name":"Independent Practitioner  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Pr\u00e9laud","sequence":"additional","affiliation":[{"name":"Advetia Centre Hospitalier V\u00e9t\u00e9rinaire  V\u00e9lizy Villacoublay 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