{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:00:15Z","timestamp":1773478815926,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008788","name":"College of Veterinary Medicine, Ohio State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008788","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2026,2,28]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Pigs pose distinct challenges to the anaesthetist due to their temperament, the limitations of manual restraint and species\u2010specific anatomical features. Despite the importance of minimising stress during clinical procedures, gentle handling techniques tailored for pigs in a clinical setting have yet to be clearly described or systematically investigated.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Sixteen healthy domesticated pigs were prospectively enrolled in a clinical study evaluating \u2018combing\u2019 with a fork as a gentle tactile handling technique in a hospital setting and randomly assigned to either a combing or a control group. Responses were evaluated by a non\u2010blinded, single observer using a seven\u2010domain sedation scale and a dichotomous response scale.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Sedation scores were significantly higher for combing than control. The onset of peak sedation time was significantly faster for combing than control (5\u00a0vs. 10 minutes). Fewer (12.5%) pigs in the combing group moved away from the injection compared to 75% of control pigs.<\/jats:p>\n <\/jats:sec>\n \n Limitations<\/jats:title>\n Limitations included the injectable drug protocol used, the lack of blinding with a single observer aware of group allocation, and more than one individual performing the \u2018combing\u2019 protocol.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \u2018Combing\u2019, a gentle handling technique performed prior to intramuscular sedation, resulted in pigs being less reactive to the injection, and faster sedation onset.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/vetr.6124","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T11:11:09Z","timestamp":1764760269000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of \u2018combing\u2019 on intramuscular sedation in pigs in a clinical setting\u2014A randomised trial"],"prefix":"10.1002","volume":"198","author":[{"given":"Kaitlynn C.","family":"Ban","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-0798","authenticated-orcid":false,"given":"Carolina H. Ricco","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk A.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara E.","family":"Hampton","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Tennessee Knoxville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Bini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Lerche","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119421375.ch50"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.1016414"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2021.08.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367700780578073"},{"key":"e_1_2_11_6_1","article-title":"The impact of a stress\u2010reducing protocol on the quality of pre\u2010anaesthesia in cats","volume":"188","author":"Arg\u00fcelles J","year":"2003","journal-title":"Vet Rec."},{"key":"e_1_2_11_7_1","first-page":"246","article-title":"Determination of a sedative dose and influence of droperidol and midazolam on cardiovascular function in pigs","volume":"61","author":"Bustamante R","year":"1997","journal-title":"Can J Vet Res."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012373898-1.50019-X"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1996.57.04.529"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.258.8.883"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.55.687"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13028-020-0512-y"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2016.06.008"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2008.00443.x"},{"key":"e_1_2_11_15_1","first-page":"476","article-title":"Comparison of Telazol, Telazol\u2012ketamine, Telazol\u2012xylazine, and Telazol\u2012ketamine\u2012xylazine as chemical restraint and anesthetic induction combination in swine","volume":"43","author":"Ko JC","year":"1993","journal-title":"Lab Anim Sci."},{"key":"e_1_2_11_16_1","first-page":"290","article-title":"Increasing xylazine dose\u2010enhanced anesthetic properties of Telazol\u2012xylazine combination in swine","volume":"45","author":"Ko JC","year":"1995","journal-title":"Lab Anim Sci."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.56.359"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.6124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vetr.6124","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.6124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:32:27Z","timestamp":1773477147000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1002\/vetr.6124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,2,28]]}},"alternative-id":["10.1002\/vetr.6124"],"URL":"https:\/\/doi.org\/10.1002\/vetr.6124","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]}}}