{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:00:26Z","timestamp":1773478826107,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2026,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Folate deficiency has been reported in humans and dogs with immune\u2010mediated haemolytic anaemia (IMHA) but not in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cats with IMHA and without primary intestinal disease were included. Serum folate was measured at varying timepoints following IMHA diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five cats (three with non\u2010associative IMHA and two with possible concurrent acute pancreatitis) were followed for a median of 300 days (range: 40\u2012540 days). Serum folate concentration was evaluated 36 times (median: 6 per cat; range: 1\u201219) and ranged from 5.1 to 20.1\u00a0ng\/mL (median: 7.4\u00a0ng\/mL), including nine samples in three cats receiving folic acid (400\u00a0\u00b5g\/day). Hypofolataemia in the 27 samples without supplementation was detected in all cats on at least one occasion (median: 3 times; range: 1\u20124) for a total of 13 episodes. The median time to detection was 13 days after diagnosis (range: 1\u2012310 days). The median haemoglobin concentration at the time of hypofolataemia was 7.01\u00a0g\/dL (range: 3.9\u20129.92 g\/dL). Oral folate supplementation normalised folate concentration (median: 16.0\u00a0ng\/mL; range: 11.8\u201220.1\u00a0ng\/mL) in all nine tested samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Small sample size and lack of a control group prevented analysing the IMHA and folate link.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hypofolataemia occurred in all five cats with IMHA, possibly due to increased demand.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.70058","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T09:00:19Z","timestamp":1764752419000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypofolataemia in five cats with immune\u2010mediated haemolytic anaemia"],"prefix":"10.1002","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3592-0360","authenticated-orcid":false,"given":"Andrea","family":"Zoia","sequence":"first","affiliation":[{"name":"Division of Internal Medicine San Marco Veterinary Clinic  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"2078","volume-title":"Textbook of veterinary internal medicine","author":"Piek CJ","year":"2017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15441"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb02836.x"},{"key":"e_1_2_11_5_1","first-page":"31","volume-title":"Small animal clinical diagnosis by laboratory methods","author":"Tvedten H","year":"1999"},{"key":"e_1_2_11_6_1","first-page":"547","article-title":"ASVPC Meeting. 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