{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:33:24Z","timestamp":1765978404452,"version":"3.48.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Dexmedetomidine commonly induces emesis in cats, increasing the risk of aspiration and discomfort. Butorphanol and maropitant have been suggested as antiemetic adjuncts, but their comparative efficacy is unclear.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Twenty healthy female cats undergoing elective ovariohysterectomy were randomly assigned to receive intravenous dexmedetomidine (25\u00a0\u00b5g\/kg) with either butorphanol (0.2\u00a0mg\/kg;\n n<\/jats:italic>\n \u00a0=\u00a010) or maropitant (1\u00a0mg\/kg;\n n<\/jats:italic>\n \u00a0=\u00a010). Incidences of emesis, retching, sialorrhea and lip licking were recorded for 30 minutes. Physiological parameters and sedation scores were assessed at set intervals. Anaesthesia was induced with propofol and maintained with isoflurane. Intubation quality, recovery and postoperative pain were evaluated for 180 minutes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The incidence of emesis was very low (0\/10 in butorphanol and 1\/10 in maropitant;\n p<\/jats:italic>\n > 0.05). Nausea\u2010associated behaviours were similar between groups (\n p<\/jats:italic>\n > 0.05). Both protocols caused transient decreases in heart rate and mean arterial pressure, while oxygen saturation and temperature remained stable. Sedation was deeper with butorphanol at early time points, with a mean difference in the sedation score of 2.3 (95% confidence interval [CI]: 0.9\u20123.7;\n p<\/jats:italic>\n < 0.05). Intubation and recovery were comparable between the groups (\n p<\/jats:italic>\n > 0.05). Pain scores were significantly lower in the maropitant group at 120 minutes, with a mean pain score difference of 3.2 (95% CI: 0.7\u20125.8;\n p<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Limitations<\/jats:title>\n The small sample size and restriction to healthy female cats may limit generalisability.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In this study, the incidence of dexmedetomidine\u2010induced emesis was minimal in cats receiving either butorphanol or maropitant as adjuncts. Butorphanol was associated with deeper early sedation, whereas maropitant was linked to lower postoperative pain scores. These findings suggest that adjunct selection may be tailored according to individual perioperative priorities.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/vetr.70177","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:30:44Z","timestamp":1765978244000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the antiemetic, sedative and analgesic effects of butorphanol and maropitant in combination with dexmedetomidine in cats undergoing ovariohysterectomy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2620-897X","authenticated-orcid":false,"given":"S\u0131tk\u0131can","family":"Okur","sequence":"first","affiliation":[{"name":"Department of Veterinary Surgery Faculty of Veterinary Medicine Atat\u00fcrk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2787-1249","authenticated-orcid":false,"given":"B\u00fc\u015fra","family":"Baykal","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery Faculty of Veterinary Medicine Atat\u00fcrk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2733-2155","authenticated-orcid":false,"given":"Damla T.","family":"Okur","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Veterinary Medicine Atat\u00fcrk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4222-3718","authenticated-orcid":false,"given":"Taner","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery Faculty of Veterinary Medicine Atat\u00fcrk University Erzurum 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cats: a dose\u2010finding study","volume":"31","author":"Slingsby LS","year":"2008","journal-title":"J Vet Pharmacol Ther"},{"issue":"6","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/vaa.12260","article-title":"The effect of butorphanol on the incidence of dexmedetomidine\u2010induced emesis in cats","volume":"42","author":"Papastefanou AK","year":"2015","journal-title":"Vet Anaesth Analg"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/00000542-199206000-00001","article-title":"The locus coeruleus: site of hypnotic actions of \u03b12\u2010adrenoceptor agonists?","volume":"76","author":"Scheinin M","year":"1992","journal-title":"Anesthesiology"},{"issue":"6","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1097\/00000542-199412000-00029","article-title":"Perturbation of ion channel conductance alters the hypnotic response to the alpha 2\u2010adrenergic agonist dexmedetomidine in the locus coeruleus of the rat","volume":"81","author":"Nacif\u2010Coelho C","year":"1994","journal-title":"Anesthesiology"},{"key":"e_1_2_12_7_1","unstructured":"AnsahOB.Use of the alpha\u20102\u2010adrenoceptor agonists medetomidine and dexmedetomidine in the sedation and analgesia of domestic cats. Doctoral Dissertation. University of Helsinki; 2004."},{"issue":"1","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","DOI":"10.1002\/vms3.70152","article-title":"The effect of maropitant, ondansetron and metoclopramide on dexmedetomidine\u2010induced vomiting in cats","volume":"11","author":"Bedir AG","year":"2025","journal-title":"Vet Med Sci"},{"issue":"5","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1467-2995.2010.00555.x","article-title":"Sedative and cardiorespiratory effects of dexmedetomidine and buprenorphine administered to cats via oral transmucosal or intramuscular routes","volume":"37","author":"Santos LCP","year":"2010","journal-title":"Vet Anaesth Analg"},{"issue":"12","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.2460\/javma.247.12.1415","article-title":"Assessment of dexmedetomidine and other agents for emesis induction in cats: 43 cases (2009\u20132014)","volume":"247","author":"Thawley 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