{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:02:55Z","timestamp":1781262175807,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2026,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bovine tuberculosis (TB) threatens cattle farming in England. Supplementing tuberculin skin testing with the interferon\u2010gamma blood test during TB incident (breakdown) management can enhance diagnostic sensitivity. We aimed to identify herds at greater risk of recurrence depending on their recent TB history to inform targeted interferon\u2010gamma test deployment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using observational data, we analysed TB breakdowns in herds with a lesion\u2010positive or bacteriologically positive (officially tuberculosis free\u2010withdrawn [OTF\u2010W]) breakdown in the High\u2010Risk Area or six\u2010monthly surveillance section of the Edge Area of England between 2018 and 2020. Multivariable logistic regression assessed the odds of recurrence 18 months post\u2010breakdown, based on TB status in the 18 months prior (OTF\u2010W, OTF\u2010suspended [OTF\u2010S], none). Covariates previously identified as recurrence risk factors were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Herds with an OTF\u2010W breakdown history had significantly higher odds of recurrence than those with no history: odds ratio [OR] 1.3 (95% confidence interval [CI]: 1.1\u20121.6). OTF\u2010S history did not confer increased risk: OR 0.9 (95% CI: 0.8\u20121.1). A large herd size was another significant risk factor for recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Limited covariates were included in the analysis, which means that other factors potentially driving the recurrence of disease within herds may have been overlooked.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This analysis supports prioritising interferon\u2010gamma testing of OTF\u2010W breakdown herds with an OTF\u2010W history but not an OTF\u2010S history. Large herds, irrespective of breakdown history, may also benefit. Effective interventions against TB recurrence require further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.70335","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:09:53Z","timestamp":1772957393000},"source":"Crossref","is-referenced-by-count":0,"title":["Bovine tuberculosis history as a risk factor for recurrence in English cattle herds experiencing a breakdown"],"prefix":"10.1002","volume":"198","author":[{"given":"Daisy","family":"Duncan","sequence":"first","affiliation":[{"name":"Department of Epidemiological Sciences WOAH Collaborating Centre in Risk Analysis and Modelling Animal and Plant Health Agency  Addlestone UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Epidemiological Sciences WOAH Collaborating Centre in Risk Analysis and Modelling Animal and Plant Health Agency  Addlestone 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