{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:08:46Z","timestamp":1784290126202,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2026,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To our knowledge, the effect of sedation with romifidine on the grading of laryngeal function in horses has not been studied. Our objective was to examine the effects of romifidine on the grading of laryngeal function and the cross\u2010sectional area of the rima glottis (CSARG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten horses underwent three endoscopic examinations of the larynx: once while unsedated (group R1), once after being sedated with romifidine (0.04\u00a0mg\/kg intravenously; group R2) and once again, while still sedated, after receiving a repeat dose of romifidine (0.08\u00a0mg\/kg intravenously, total dose; group R3). The recorded examinations were randomised and examined by three blinded reviewers who graded laryngeal function. The CSARG was measured from still images obtained during peak inspiration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sedation had no significant effect on the endoscopic laryngeal function grade assigned. There was no statistical difference in CSARG between Groups R1 and R2 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.164). Significant reduction in CSARG was noted between Groups R1 and R3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and Groups R2 and R3 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.045).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>The low number of horses examined may have resulted in the analyses being insufficiently powered. As such, the findings should be interpreted cautiously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A dose of 0.04\u00a0mg\/kg romifidine administered intravenously had no significant effect on horses\u2019 laryngeal function grade and CSARG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.70804","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T08:04:07Z","timestamp":1779437047000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect of romifidine on endoscopic grading of laryngeal function in horses"],"prefix":"10.1002","volume":"199","author":[{"given":"Catherine","family":"Murphy","sequence":"first","affiliation":[{"name":"Centre of Equine Health, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Lyon, VetAgro Sup University of Lyon  Marcy L\u2019\u00c9toile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Baglioni","sequence":"additional","affiliation":[{"name":"Centre of Equine Health, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Lyon, VetAgro Sup University of Lyon  Marcy L\u2019\u00c9toile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier M.","family":"Lepage","sequence":"additional","affiliation":[{"name":"Centre of Equine Health, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Lyon, VetAgro Sup University of Lyon  Marcy L\u2019\u00c9toile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Centre of Equine Health, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Lyon, VetAgro Sup University of Lyon  Marcy L\u2019\u00c9toile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Centre of Equine Health, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Lyon, VetAgro Sup University of Lyon  Marcy L\u2019\u00c9toile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Burke","sequence":"additional","affiliation":[{"name":"Centre of Equine Health, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Lyon, VetAgro Sup University of Lyon  Marcy L\u2019\u00c9toile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Gangl","sequence":"additional","affiliation":[{"name":"Centre of Equine Health, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Lyon, VetAgro Sup University of Lyon  Marcy L\u2019\u00c9toile France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"The equine manual E\u2010book","author":"Higgins AJ","year":"2013"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.14474"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-4771-8.00026-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.13712"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/vetr.1483"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.962"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516402776181169"},{"key":"e_1_2_11_9_1","volume-title":"Equine surgery","author":"Stick JA","year":"2018"},{"key":"e_1_2_11_10_1","first-page":"173","volume-title":"Proceedings of the fifteenth Bain\u2010Fallon memorial lectures","author":"Lane JG","year":"1993"},{"key":"e_1_2_11_11_1","first-page":"93","volume-title":"Proceedings of a workshop on equine recurrent laryngeal neuropathy","author":"Dixon PM","year":"2004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12061"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516406778400619"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.14110"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.12891"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1991.tb02731.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1991.tb00332.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516407X204177"},{"key":"e_1_2_11_19_1","unstructured":"Tattersalls.2025 Tattersalls Sales\u2014Repository: a secure online facility for the centralised viewing of pre\u2010sale x\u2010rays and video endoscopies.Newmarket (UK):Tattersalls;2025. Accessed October 13 2025.https:\/\/secure.tattersalls.com:8443\/4DCGI\/Sale\/Documentation\/WSD01493.pdf"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1991.tb00331.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12331"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-0481-62-5-334"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2010.00108.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13030"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516409X423073"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2024.106259"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.70804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vetr.70804","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.70804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:52:24Z","timestamp":1784289144000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1002\/vetr.70804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,7,25]]}},"alternative-id":["10.1002\/vetr.70804"],"URL":"https:\/\/doi.org\/10.1002\/vetr.70804","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]}}}