{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:02:12Z","timestamp":1779796932497,"version":"3.53.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the feasibility of a proprietary collagen\u2013elastin hydrogel microparticulate (CEHM) intra\u2010articular injection into canine stifles with suspected cranial cruciate disease (CCD) and osteoarthritis (OA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty client\u2010owned dogs over 6 months of age and diagnosed with suspected unilateral CCD or OA, without prior surgical or medical intervention, were enroled. A Simon's two\u2010stage clinical trial design was used, as previously described in human literature. Each stifle was injected with the CEHM device and followed over 84 days. Serial examinations with modified Glasgow composite pain score (mGCPS) and additional subjective clinician\u2010 and owner\u2010derived scoring scales were obtained at predefined time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010two dogs had a 25% or greater improvement in the primary measured parameter, mGCPS, giving a response rate of 55%. There were also statistically significant improvements in all other subjectively measured parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>The limitations of the study were the lack of objective lameness measurements, surgical confirmation of CCD, blinding, randomisation and a control population to account for possible placebo effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The CEHM device demonstrates feasibility in suspected canine CCD and stifle OA, within the measured subjective parameters of this proof\u2010of\u2010concept study. Additional objective investigations are recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.70805","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:04:09Z","timestamp":1779793449000},"source":"Crossref","is-referenced-by-count":0,"title":["Short\u2010term outcomes following intra\u2010articular biomaterial injection for pain secondary to stifle osteoarthritis and suspected cranial cruciate ligament injury in dogs"],"prefix":"10.1002","author":[{"given":"Erik B.","family":"Kleeman","sequence":"first","affiliation":[{"name":"Bridger Veterinary Specialists  Bozeman Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libbey","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Wisconsin Veterinary Referral Center Waukesha  Waukesha Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Blaeser","sequence":"additional","affiliation":[{"name":"Bulger Veterinary Hospital  Lawrence Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Reed","sequence":"additional","affiliation":[{"name":"Wisconsin Veterinary Referral Center Racine\/Kenosha  Somers Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy Fryer","family":"Hillman","sequence":"additional","affiliation":[{"name":"Veterinary Specialty Hospital San Diego  Sorrento Valley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel D.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Ethos Veterinary Health  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.2460\/ajvr.1985.46.09.1842","article-title":"Correlative biomechanical and histologic study of the cranial cruciate ligament in dogs","volume":"46","author":"Vasseur PB","year":"1985","journal-title":"Am J Vet Res."},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.1052327","article-title":"Stifle kinematics in 4 dogs with cranial cruciate ligament insufficiency treated by CORA\u2010based leveling osteotomy","volume":"9","author":"Tinga S","year":"2022","journal-title":"Front Vet Sci."},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/jvet.2002.31041","article-title":"Effect of tibial plateau leveling on stability of the canine cranial cruciate\u2010deficient stifle joint: an in vitro 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