{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:57:55Z","timestamp":1785499075176,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Oral non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) are commonly used for analgesia in dogs with spontaneous chronic corneal epithelial defects (SCCEDs). Topical NSAIDs can delay epithelialisation and promote stromal melting, but the safety of systemic NSAIDs in SCCEDs is unknown.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Medical records of dogs with SCCEDs (2018\u20132024) were reviewed. \u00a0Affected eyes were grouped by systemic therapy at presentation: oral NSAIDs versus no oral NSAIDs. All cases underwent a corneal debridement procedure. The primary outcome was time to corneal re\u2010epithelialisation; secondary outcomes were number of procedures needed for healing and complications (stromal melting, descemetocoele, perforation).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 186 SCCEDs in 170 dogs met inclusion criteria; 136 were treated with an oral NSAID and 50 without. The median \u00b1 standard error healing time was 15 \u00b1 1.0\u00a0days (range: 6\u201374) for the NSAID group and 15 \u00b1 1.5\u00a0days (range: 6\u201349) for the no\u2010NSAID group (\n p<\/jats:italic>\n = 0.638). The median number of procedures required before healing was one (range: 1\u20133) in both the NSAID and no\u2010NSAID groups (\n p<\/jats:italic>\n = 0.210). No cases developed stromal melting, descemetocoele or perforation.\n <\/jats:p>\n <\/jats:sec>\n \n Limitations<\/jats:title>\n The retrospective, non\u2010randomised design limits the wider generalisability of the findings.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Short\u2010term oral NSAID therapy did not delay epithelial healing or increase complications, supporting their safe use in dogs with SCCEDs.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/vetr.71023","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:04:23Z","timestamp":1785495863000},"source":"Crossref","is-referenced-by-count":0,"title":["Oral non\u2010steroidal anti\u2010inflammatory drugs do not delay corneal healing in dogs with spontaneous chronic corneal epithelial defects: A retrospective cohort of 186 ulcers"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4909-5599","authenticated-orcid":false,"given":"Kaitlyn","family":"Scheunemann","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Iowa State University Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8048-7004","authenticated-orcid":false,"given":"Rachel","family":"Allbaugh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Iowa State University Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-0127","authenticated-orcid":false,"given":"Lionel","family":"Sebbag","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1463-5224.2012.01026.x","article-title":"Management of spontaneous chronic corneal epithelial defects (SCCEDs) in dogs with diamond burr debridement and placement of a bandage contact lens","volume":"16","author":"Gosling AA","year":"2013","journal-title":"Vet Ophthalmol"},{"issue":"6","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/vop.12460","article-title":"Diamond burr debridement vs grid keratotomy in canine SCCED with scanning electron microscopy diamond burr tip analysis","volume":"20","author":"Spertus CB","year":"2017","journal-title":"Vet Ophthalmol"},{"issue":"2","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/vop.13203","article-title":"Superficial keratectomy for the 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corneal epithelial defects in dogs","volume":"42","author":"Bentley E","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/vop.12202","article-title":"Effect of corneal contact lens wear on healing time and comfort post LGK for treatment of SCCEDs in Boxers","volume":"18","author":"Wooff PJ","year":"2015","journal-title":"Vet Ophthalmol"},{"issue":"6","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/vop.12556","article-title":"Treatment of spontaneous chronic corneal epithelial defects (SCCEDs) with diamond burr debridement vs combination diamond burr debridement and superficial grid keratotomy","volume":"21","author":"Wu D","year":"2018","journal-title":"Vet Ophthalmol"},{"issue":"6","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/vop.12838","article-title":"Cotton\u2010tip debridement, scalpel blade 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