{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:55:03Z","timestamp":1790657703829,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intramuscular injection of sedatives into different muscles may affect the quality of sedation. Subcutaneous injection is less painful but has a less predictable effect; however, administration at Governing Vessel 20 (GV20) may improve sedation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy\u2010three dogs were premedicated with medetomidine and methadone. The route of administration was determined by random allocation: subcutaneous injection at GV20 (GV\u201020), intramuscular injection into the quadriceps muscles (IM\u2010Q) or intramuscular injection into the epaxial lumbar muscles (IM\u2010L). Sedation was scored at 3, 7 and 10 minutes after injection using a simple descriptive scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Scores were higher in groups IM\u2010Q and GV\u201020 than in group IM\u2010L and did not differ significantly between GV\u201020 and IM\u2010Q at any time point. Scores differed significantly between IM\u2010L and IM\u2010Q at 3 minutes, between IM\u2010L and both IM\u2010Q and GV\u201020 at 7 minutes, and between GV\u201020 and IM\u2010L at 10 minutes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Differences in patient size between groups, inter\u2010rater variability and the use of allometric dosing may have affected the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The quality of sedation following injection of methadone and medetomidine at GV20 does not differ significantly from that following injection into the quadriceps muscles, and the injection is well tolerated. Injection into the epaxial lumbar muscles results in less profound sedation, possibly because of inadvertent subcutaneous injection or anatomical differences in tissue perfusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.71213","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:59:07Z","timestamp":1790654347000},"source":"Crossref","is-referenced-by-count":0,"title":["Randomised, blinded clinical trial comparing dogs\u2019 sedation scores following methadone\u2013medetomidine injection at Governing Vessel 20, the epaxial lumbar muscles or the quadriceps muscles"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1065-5988","authenticated-orcid":false,"given":"Hillen","family":"Florence","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine and Science University of Nottingham  Nottingham 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