{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:03:38Z","timestamp":1790820218605,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Metabolic acidosis is common in dogs with chronic kidney disease (CKD) and induces ventilatory compensation. Systemic arterial hypertension frequently accompanies CKD, but its influence on the ventilatory response remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This ambispective observational study included 42 dogs with CKD and metabolic acidosis. Venous partial pressure of carbon dioxide (PCO\n                      <jats:sub>2<\/jats:sub>\n                      ) was compared between normotensive (systolic blood pressure [SBP]\u00a0&lt;\u00a0150\u00a0mmHg) and hypertensive (SBP\u00a0\u2265\u00a0150\u00a0mmHg) dogs. Pearson's correlation and multiple linear regression were used to evaluate base excess (BE), SBP and serum creatinine as predictors of venous PCO\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Metabolic acidosis severity (BE) was associated with ventilatory response (PCO\n                      <jats:sub>2<\/jats:sub>\n                      ) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), whereas SBP showed no association. Mean PCO\n                      <jats:sub>2<\/jats:sub>\n                      did not differ between normotensive and hypertensive dogs (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.373). Serum creatinine independently predicted PCO\n                      <jats:sub>2<\/jats:sub>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), with higher concentrations associated with higher PCO\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>The observational design, limited sample size and incomplete International Renal Interest Society staging may limit the generalisability of the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In dogs with CKD and metabolic acidosis, ventilatory compensation, assessed by venous PCO\n                      <jats:sub>2<\/jats:sub>\n                      , was primarily associated with the severity of the metabolic disturbance and showed no significant association with blood pressure status. Compensation may be attenuated as azotaemia worsens.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.71219","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:39:21Z","timestamp":1790818761000},"source":"Crossref","is-referenced-by-count":0,"title":["Ventilatory compensation for metabolic acidosis is independent of hypertension in dogs with chronic kidney disease"],"prefix":"10.1002","author":[{"given":"Let\u00edcia","family":"da Silva Rueda","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Leal Raymundo","family":"Pessina","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Luiz Salardani","family":"Senhorello","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Prevedello","family":"Franco","sequence":"additional","affiliation":[{"name":"University of Mar\u00edlia (Unimar)  Mar\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo S\u00e9rgio Patto","family":"dos Santos","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Vitoria Magalh\u00e3es","family":"Dias","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Ferreira","family":"Gomes","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner Luis","family":"Ferreira","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"5","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3390\/vetsci10050363","article-title":"Serum bicarbonate deficiency in dogs with acute and chronic kidney disease","volume":"10","author":"Lippi I","year":"2023","journal-title":"Vet Sci"},{"issue":"1","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1053\/j.ajkd.2020.10.015","article-title":"Effect of bicarbonate on net acid excretion, 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