{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:42:09Z","timestamp":1772840529754,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Opioid\u2010induced respiratory compromise remains a significant challenge in etorphine\u2010immobilised wildlife. Serotonergic agonists offer a potential avenue for preventing or treating opioid\u2010induced respiratory compromise. We therefore aimed to determine whether the selective 5\u2010hydroxytryptamine receptor 4 (5\u2010HT4) agonist, BIMU\u20108, reverses opioid\u2010induced respiratory compromise in etorphine\u2010immobilised goats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Seven healthy adult goats were immobilised with etorphine, then treated with BIMU\u20108 or sterile water 5 minutes later in a randomised, prospective cross\u2010over study. Cardiorespiratory variables were measured at 1\u2010minute intervals from 4 minutes before etorphine to 15 minutes after its administration. Arterial blood gas analyses were also performed before and after etorphine administration and the respective treatments.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Intravenous injection of BIMU\u20108 attenuated etorphine\u2010induced respiratory compromise, as indicated by improvements, compared to baseline and between treatments, in respiratory rate (\n                    <jats:italic>f<\/jats:italic>\n                    <jats:sub>R<\/jats:sub>\n                    ), peripheral arterial blood oxygen saturation (SpO\n                    <jats:sub>2<\/jats:sub>\n                    ), partial pressure of arterial oxygen (PaO\n                    <jats:sub>2<\/jats:sub>\n                    ) and the alveolar\u2010arterial oxygen partial pressure gradient (P(A\u2010a)O\n                    <jats:sub>2<\/jats:sub>\n                    ). BIMU\u20108 caused an increase in heart rate and a temporary decrease in arterial blood pressure. Mild movements and slight muscle spasm occurred but BIMU\u20108 did not reverse immobilisation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Our results indicate that BIMU\u20108 may be a potential drug candidate for the treatment, or prevention, of etorphine\u2010induced respiratory compromise in immobilised ungulates.\n                  <\/jats:p>","DOI":"10.1002\/vetr.76","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T20:54:26Z","timestamp":1613854466000},"source":"Crossref","is-referenced-by-count":4,"title":["Investigation of cardiorespiratory effects of the selective 5\u2010HT4 agonist BIMU\u20108 in etorphine\u2010immobilised goats (\n                    <i>Capra aegagrus hircus<\/i>\n                    ) in a randomized, blinded and controlled trial"],"prefix":"10.1002","volume":"189","author":[{"given":"Nadine","family":"Tod","sequence":"first","affiliation":[{"name":"Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-1181","authenticated-orcid":false,"given":"Gabrielle","family":"Stalder","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology University of Veterinary Medicine Vienna  Vienna 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