{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:07:05Z","timestamp":1792516025506,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Bovine respiratory syncytial virus (BRSV) is a major problem for cattle worldwide during their first year of life. The aim of the present study was to evaluate efficacy and longevity of immunity of a live vaccine (NASYM, HIPRA) in the presence of maternally derived antibodies (MDA).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method<\/jats:bold>\n                    : Calves (36) were distributed in four groups, based on MDA status and treatment. They received NASYM or a placebo at an early age (less than two weeks) by intranasal route. Eight weeks later, animals were challenged with the Asquith strain of BRSV. Efficacy was assessed by monitoring clinical signs and mortality, PaO\n                    <jats:sub>2<\/jats:sub>\n                    , virus shedding and lung lesions. The immunological response was evaluated by measuring IgG in serum and IgA in nasal secretions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : A reduction of mortality, lung lesions, shedding and a higher PaO\n                    <jats:sub>2<\/jats:sub>\n                    was achieved in NASYM vaccinated groups, independently of MDA status. An anamnestic IgG response was observed after challenge in vaccinated animals, both in MDA+ and MDA\u2010 groups. An IgA response was also observed in vaccinated animals after vaccination and challenge.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : NASYM protected newborn calves with MDAs during the first 10 weeks of life, against a very virulent challenge that caused extensive pulmonary lesions and deaths in control animals, with just a single intranasal dose.\n                  <\/jats:p>","DOI":"10.1002\/vetr.83","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T01:36:55Z","timestamp":1611884215000},"source":"Crossref","is-referenced-by-count":10,"title":["NASYM, a live intranasal vaccine, protects young calves from bovine respiratory syncytial virus in the presence of maternal antibodies"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-2719","authenticated-orcid":false,"given":"Elena","family":"Marzo","sequence":"first","affiliation":[{"name":"Department of R&amp;D Preclinical and clinical development Hipra Scientific S.L.U.  Avda. La Selva 135 Amer 17170 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Montbrau","sequence":"additional","affiliation":[{"name":"Department of R&amp;D Preclinical and clinical development Hipra Scientific S.L.U.  Avda. La Selva 135 Amer 17170 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2010Carmen","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of R&amp;D Biologics Hipra Scientific S.L.U.  Avda. La Selva 135 Amer 17170 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Roca","sequence":"additional","affiliation":[{"name":"Department of R&amp;D Experimentation and Controls Hipra Scientific S.L.U.  Avda. La Selva 135 Amer 17170 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sitj\u00e0","sequence":"additional","affiliation":[{"name":"Department of R&amp;D Biologics Hipra Scientific S.L.U.  Avda. La Selva 135 Amer 17170 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricard","family":"March","sequence":"additional","affiliation":[{"name":"Department of R&amp;D Preclinical and clinical development Hipra Scientific S.L.U.  Avda. La Selva 135 Amer 17170 Spain"},{"name":"Department of R&amp;D Experimentation and Controls Hipra Scientific S.L.U.  Avda. La Selva 135 Amer 17170 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl","family":"Gow","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon SK S7N 5B4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Lacoste","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon SK S7N 5B4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon SK S7N 5B4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813501341"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.12.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.11.1602"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.2.233"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.236.9.991"},{"key":"e_1_2_8_7_1","article-title":"Vaccinating Calves: New Information on the Effects of Maternal Immunity","volume":"8","author":"Woolums A","year":"2007","journal-title":"THE AABP PROCEEDINGS"},{"key":"e_1_2_8_8_1","first-page":"1180","article-title":"Inhibition of priming for bovine respiratory syncytial virus-specific protective immune responses following parenteral vaccination of passively immune calves","volume":"55","author":"Ellis J","year":"2014","journal-title":"Can Vet J"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.1973"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","unstructured":"NjaaBL ClarkEG JanzenE EllisJA Haines DM Diagnosis of persistent bovine viral diarrhea virus infection by immunohistochemical staining of formalin-fixed skin biopsy specimens. 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