{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:57:54Z","timestamp":1790531874820,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The therapeutic strategy of bovine respiratory disease (BRD) often involves a combination of an antibiotic with an anti\u2010inflammatory agent. Aim of this study was to evaluate the clinical effect of a new combination product containing tulathromycin and ketoprofen for the treatment of naturally occurring BRD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred and eighty animals were randomized upon diagnosis of BRD. One hundred forty animals each were treated once subcutaneously with tulathromycin\u2010ketoprofen or tulathromycin. Rectal temperature of each animal was measured at 1, 2, 4, 6, 8, 10, 12 and 24 h post\u2010treatment. Individual respiration and depression scores were determined at 6 h post\u2010treatment. Daily rectal temperature, respiration and depression scores were recorded from day 2 to 14 and on day 21.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The tulathromycin\u2010ketoprofen and tulathromycin treatment group demonstrated a treatment success rate of 94.2% and 95.0%, respectively and a relapse rate of 3.8% and 4.0%, respectively. Tulathromycin\u2010ketoprofen demonstrated superior pyrexia control compared to tulathromycin within the first 24 h following treatment. Tulathromycin\u2010ketoprofen\u2010treated animals demonstrated faster improvement of their clinical symptoms (respiration and depression score).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Efficacy of tulathromycin\u2010ketoprofen for the treatment of BRD was non\u2010inferior to tulathromycin. The combination product clearly exhibited more pronounced fever control than tulathromycin which is considered beneficial for animal welfare.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.834","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:02:17Z","timestamp":1630627337000},"source":"Crossref","is-referenced-by-count":17,"title":["Treatment of bovine respiratory disease with a single administration of tulathromycin and ketoprofen"],"prefix":"10.1002","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2891-0298","authenticated-orcid":false,"given":"Jenne","family":"De Koster","sequence":"first","affiliation":[{"name":"Veterinary Medicine Research and Development Zoetis  Zaventem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jezaniah\u2010Kira","family":"Tena","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Research and Development Zoetis  Kalamazoo Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Stegemann","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Research and Development Zoetis  Zaventem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-8-26"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2016.08.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189090"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2012.2669"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1466252314000176"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2020.03.002"},{"key":"e_1_2_9_8_1","first-page":"115","article-title":"A therapeutic strategy for treatment of the bovine respiratory disease complex: The rationale for the combination of a nonsteroidal anti\u2010inflammatory drug with an antibiotic","volume":"15","author":"Lekeux P","year":"2007","journal-title":"Cattle Pract"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2006011"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2011.12.003"},{"key":"e_1_2_9_11_1","unstructured":"National Center for Biotechnology Information. 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