{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:28:13Z","timestamp":1779103693771,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The potent sedative medetomidine is a commonly used adjunct for the immobilisation of non\u2010domestic mammals. However, its use is associated with pronounced cardiovascular side effects, such as bradycardia, vasoconstriction and decreased cardiac output. We investigated the effects of the peripherally\u2010acting alpha\u20102\u2010adrenoceptor antagonist vatinoxan on cardiovascular properties in medetomidine\u2010tiletamine\u2010zolazepam anaesthetised wild boar (\n                      <jats:italic>Sus scrofa<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve wild boars, anaesthetised twice with medetomidine (0.1\u00a0mg\/kg) and tiletamine\/zolazepam (2.5\u00a0mg\/kg) IM in a randomised, crossover study, were administered (0.1\u00a0mg\/kg) vatinoxan or an equivalent volume of saline IV (control). Cardiovascular variables, including heart rate (HR), mean arterial blood pressure (MAP), pulmonary artery pressure (PAP), pulmonary artery occlusion pressure (PAOP) and cardiac output (CO), were assessed 5 min prior to vatinoxan\/saline administration until the end of anaesthesia 30 min later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MAP (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.0001), MPAP (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and MPAOP (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.0001) significantly decreased from baseline after vatinoxan until the end of anaesthesia. HR increased significantly (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.0001) from baseline after vatinoxan administration. However, the effect on HR subsided 3 min after vatinoxan. All variables remained constant after saline injection. There was no significant effect of vatinoxan or saline on CO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vatinoxan significantly reduced systemic and pulmonary artery hypertension, induced by medetomidine in wild boar.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vetr.835","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:34:42Z","timestamp":1630542882000},"source":"Crossref","is-referenced-by-count":5,"title":["Cardiovascular effects of intravenous vatinoxan in wild boars (\n                    <i>Sus scrofa<\/i>\n                    ) anaesthetised with intramuscular medetomidine\u2010tiletamine\u2010zolazepam"],"prefix":"10.1002","volume":"190","author":[{"given":"Joy","family":"Einwaller","sequence":"first","affiliation":[{"name":"Research Institute of Wildlife Ecology Department of Interdisciplinary Life Sciences University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leith C. R.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Paraclinical Sciences and Centre for Veterinary Wildlife Studies Faculty of Veterinary Science University of Pretoria  Onderstepoort South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Auer","sequence":"additional","affiliation":[{"name":"Clinical Unit of Anaesthesiology and Perioperative Intensive\u2010Care Medicine University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja","family":"Raekallio","sequence":"additional","affiliation":[{"name":"Department of Equine and Small Animal Medicine Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Nowack","sequence":"additional","affiliation":[{"name":"Research Institute of Wildlife Ecology Department of Interdisciplinary Life Sciences University of Veterinary Medicine Vienna  Vienna Austria"},{"name":"School of Biological and Environmental Sciences Liverpool John Moores University  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Haw","sequence":"additional","affiliation":[{"name":"Research Institute of Wildlife Ecology Department of Interdisciplinary Life Sciences University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Vetter","sequence":"additional","affiliation":[{"name":"Research Institute of Wildlife Ecology Department of Interdisciplinary Life Sciences University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Painer","sequence":"additional","affiliation":[{"name":"Research Institute of Wildlife Ecology Department of Interdisciplinary Life Sciences University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-1181","authenticated-orcid":false,"given":"Gabrielle","family":"Stalder","sequence":"additional","affiliation":[{"name":"Research Institute of Wildlife Ecology Department of Interdisciplinary Life Sciences University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"EnqvistK ArnemoJM LemelJP TruveJ.Medetomidine\/tiletamine\u2010zolazepam and medetomidine\/butorphanol\/tiletamine\u2010zolazepam: a comparison of two anesthetic regimens for surgical implantation of intraperitoneal radiotransmitters in free\u2010ranging juvenile European Wild Boars (Sus scrofa scrofa). Florida:American Association of Zoo Veterinarians;2000."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-9-107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-7397-8.00058-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2005.00233.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs059225s"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(96)90052-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.56.359"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2008.00403.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2010.01242.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.5.587"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2018.07.007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12486"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.79.9.921"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12158"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12238"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12397"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1638\/2018-0030"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2019.10.011"},{"key":"e_1_2_10_20_1","unstructured":"R Core Team. R: a language and environment for statistical computing.Vienna Austria: R Foundation for Statistical Computing;2017."},{"key":"e_1_2_10_21_1","volume-title":"An R companion to applied regression","author":"Fox J","year":"2019"},{"key":"e_1_2_10_22_1","unstructured":"PinheiroJ BatesD DebroyS SarkarD R Development Core Team. Linear and nonlinear mixed effects models.2017.http:\/\/CRAN.R\u2010project.org\/package=nlme. Accessed 5 June 2020."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v069.i01"},{"key":"e_1_2_10_24_1","first-page":"1215","article-title":"Fitting linear mixed\u2010effects models using lme4","volume":"23","author":"Bates D","year":"2014","journal-title":"J Stat Softw"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470376478.ch6"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2016.04.006"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2009.01156.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12385"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.08.019"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.79.4.376"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12354"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.042671"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.79.7.711"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1992.tb03565.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/47.11.1141"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2017.02.010"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.69.6.728"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119421375.ch2"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2008.00369.x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8000"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.T649"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12094"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vetr.835","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vetr.835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T06:14:50Z","timestamp":1761632090000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1002\/vetr.835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/vetr.835"],"URL":"https:\/\/doi.org\/10.1002\/vetr.835","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]},"article-number":"e835"}}