{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:36:05Z","timestamp":1777649765671,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Meticillin\u2010resistant\n                    <jats:italic>Staphylococcus pseudintermedius<\/jats:italic>\n                    (MRSP) is a multidrug\u2010resistant canine pathogen with a low zoonotic potential. This study investigated MRSP carriage and clearance through topical antimicrobial therapy and household cleaning in dogs recovered from MRSP infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : Dogs were swabbed for MRSP carriage; household contamination was assessed using contact plates. Carrier dogs were allocated randomly to receive topical fusidic acid and chlorhexidine\/miconazole treatment combined with owners implementing a household hygiene protocol (H&amp;T) or implementation of hygiene alone (H) over three weeks. Carriage\u2010negative dogs were monitored monthly. The relatedness of isolates over time was investigated by pulsed\u2010field gel electrophoresis (PFGE).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : At inclusion, MRSP carriage was confirmed in 31\/46 (67.4%) index dogs and 16\/24 (66.7%) contact dogs, and contamination was found in 18\/40 (45%) environments. In dogs completing all cycles, interventions cleared carriage in 5\/9 (55.6%) dogs in group H&amp;T and 2\/6 (33.3%) in group H. Environmental contamination was infrequent but associated with carrier dogs (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.047). Monthly monitoring of initially negative dogs showed intermittent carriage in 9\/14 dogs. PFGE\u2010concordance was found among all 34 MRSP isolated from eight index dogs over time.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : MRSP carriage was common in dogs after recovery from infection. Topical antimicrobial therapy temporarily eliminated carriage but recurrence was frequent. Management efforts must include the prevention of recurrent infections and hygiene.\n                  <\/jats:p>","DOI":"10.1002\/vetr.937","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T21:40:39Z","timestamp":1632778839000},"source":"Crossref","is-referenced-by-count":17,"title":["Effect of topical antimicrobial therapy and household cleaning on meticillin\u2010resistant\n                    <i>Staphylococcus pseudintermedius<\/i>\n                    carriage in dogs"],"prefix":"10.1002","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4601-4566","authenticated-orcid":false,"given":"Si\u00e2n\u2010Marie","family":"Frosini","sequence":"first","affiliation":[{"name":"Department of Clinical Services and Sciences Royal Veterinary College University of London  North Mymms Hertfordshire 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epizootics Centre for Infection Medicine Department of Veterinary Medicine Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0446-3729","authenticated-orcid":false,"given":"Anette","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Department of Clinical Services and Sciences Royal Veterinary College University of London  North Mymms Hertfordshire 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