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NIR\u2010PIT uses deep\u2010penetrable NIR light to induce physicochemical changes in the antibody\u2013photosensitizer conjugate (APC), leading to resultant necrosis and immunogenic cell death (ICD) of the cancer cells. Alternatively, other types of photomedicine use photosensitizers to convert absorbed light energy either into reactive oxygen species for photodynamic therapy (PDT) or into heat for photothermal therapy (PTT). ICD is a unique and relevant outcome of NIR\u2010PIT because it induces long\u2010lasting antitumor host immunity, which overcomes the immunosuppressive network of cancer. Due to its high specificity and durable antitumor effects, NIR\u2010PIT is now considered a promising cancer therapy, and optimized NIR\u2010PIT is readily expanding its applicability to many different types of cancer. Along with the traditional method of NIR\u2010PIT, new avenues in its realm of treatment are currently being explored, such as the targeting of other immunosuppressive elements, delivery of NIR light through a catheter, real\u2010time imaging for tumor detection, and the use of tumor\u2010seeking small molecules for improved efficacy and safety. In addition, its effect on hyperpermeability has opened a door for a wide array of combination therapies with other modalities. This review summarizes the recent findings in clinical and preclinical studies of NIR\u2010induced photomedicine and its future significance in the field of cancer research.<\/jats:p>","DOI":"10.1002\/viw.20200110","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T07:22:14Z","timestamp":1630048934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Quickly evolving near\u2010infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment"],"prefix":"10.1002","volume":"3","author":[{"given":"Hailey","family":"Monaco","sequence":"first","affiliation":[{"name":"Gordon Center for Medical Imaging Department of Radiology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4096-9695","authenticated-orcid":false,"given":"Shinya","family":"Yokomizo","sequence":"additional","affiliation":[{"name":"Gordon Center for Medical Imaging Department of Radiology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Radiological Sciences Tokyo Metropolitan University  Arakawa Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7982-6483","authenticated-orcid":false,"given":"Hak Soo","family":"Choi","sequence":"additional","affiliation":[{"name":"Gordon Center for Medical Imaging Department of Radiology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-3257","authenticated-orcid":false,"given":"Satoshi","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Gordon Center for Medical Imaging Department of Radiology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00156"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2018.4661"},{"key":"e_1_2_13_2_3","volume-title":"Cancer: Disease Control Priorities","author":"Dare A. 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