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It remains unclear whether acidosis further promotes SARS\u2010CoV\u20102 infection in patients, making virus removal difficult. For antacid therapy, sodium bicarbonate poses great risks caused by sodium overload, bicarbonate side effects, and hypocalcemia. Therefore, new antacid antidote is urgently needed. Our study showed that an acidosis\u2010related pH of 6.8 increases SARS\u2010CoV\u20102 receptor angiotensin\u2010converting enzyme 2 (ACE2) expression on the cell membrane by regulating intracellular microfilament polymerization, promoting SARS\u2010CoV\u20102 pseudovirus infection. Based on this, we synthesized polyglutamic acid\u2010PEG materials, used complexation of calcium ions and carboxyl groups to form the core, and adopted biomineralization methods to form a calcium carbonate nanoparticles (CaCO<jats:sub>3<\/jats:sub>\u2010NPs) nanoantidote to neutralize excess hydrogen ions (H<jats:sup>+<\/jats:sup>), and restored the pH from 6.8 to approximately 7.4 (normal blood pH). CaCO<jats:sub>3<\/jats:sub>\u2010NPs effectively prevented the heightened SARS\u2010CoV\u20102 infection efficiency due to pH 6.8. Our study reveals that acidosis\u2010related pH promotes SARS\u2010CoV\u20102 infection, which suggests the existence of a positive feedback loop in which SARS\u2010CoV\u20102 infection\u2010induced acidosis enhances SARS\u2010CoV\u20102 infection. Therefore, antacid therapy for acidosis COVID\u201019 patients is necessary. CaCO<jats:sub>3<\/jats:sub>\u2010NPs may become an effective antacid nanoantidote superior to sodium bicarbonate.<\/jats:p>","DOI":"10.1002\/viw.20220004","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T05:45:25Z","timestamp":1651470325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nanoantidote for repression of acidosis pH promoting COVID\u201019 infection"],"prefix":"10.1002","volume":"3","author":[{"given":"Qidong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Shanghai Fourth People's Hospital, School of Medicine, Tongji University  Shanghai P. R. China"},{"name":"Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopedic Department, Tongji Hospital, School of Medicine, Tongji University  Shanghai P. R. 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