{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:13Z","timestamp":1772118793179,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Surgical interventions are recommended for cases of advanced mitral regurgitation, however, limited facilities are available. The most prominent complication in such procedures is heparin\u2010derived bleeding. An alternative anticoagulant to heparin, nafamostat mesilate (NM), can reduce the occurrence of complications associated with heparin such as bleeding or shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the utility and safety of using NM during anaesthesia in canines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six healthy adult Beagle dogs were anaesthetised, and NM was administered intravenously as a 10\u00a0mg\/kg bolus dose over 5\u00a0min, followed by a continuous infusion of 10\u00a0mg\/kg\/h over 20\u00a0min. Blood tests and blood pressure measurements were performed at 0, 5, 25 and 55\u00a0min after NM administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Activated thromboplastin times at 0, 25 and 55\u00a0min were 13.0 \u00b1 0.7 s, 106.7 \u00b1 13.3 s and 28.2 \u00b1 2.9 s, respectively, with a significant difference between 0 and 25\u00a0min (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01) only. No significant differences were observed in prothrombin time, antithrombin, fibrinogen and fibrin degradation product concentrations between timepoints. Activated clotting times (ACTs) at 0, 5, 25 and 55\u00a0min were 119.5 \u00b1 9.6 s, 826.7 \u00b1 78.6 s, 924.8 \u00b1 42.4 s and 165.2 \u00b1 13.5 s, respectively. Significant differences were observed between 0 and 5\u00a0min (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05) and between 0 and 25\u00a0min (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Blood pressure changes occurred in four dogs (66.7%). No other serious adverse effects were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ACT results indicated that NM use in anaesthetised healthy dogs was sufficient to obtain procedural anticoagulation with minimal adverse effects. However, these preliminary data require validation in further studies on cardiopulmonary bypass surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1002","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T05:45:17Z","timestamp":1669009517000},"page":"68-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility and safety of nafamostat mesilate for anticoagulation in dogs"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4240-2134","authenticated-orcid":false,"given":"Noriko","family":"Isayama","sequence":"first","affiliation":[{"name":"Department of Cardiology Ueno no Mori Animal Hospital  Taito Tokyo Japan"},{"name":"Department of Cardiovascular Surgery The Heart Institute of Japan Tokyo Women's Medical University  Shinjyuku\u2010ku Tokyo 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