{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T16:10:37Z","timestamp":1747152637225,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KN 1097\/3\u20102 to SK","RO 3055\/2\u20102 to CR"],"award-info":[{"award-number":["KN 1097\/3\u20102 to SK","RO 3055\/2\u20102 to CR"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Treponema pallidum<\/jats:italic> (<jats:italic>TP<\/jats:italic>) is a spirochaete bacterium with subspecies that in humans cause syphilis (subsp. <jats:italic>pallidum<\/jats:italic>), bejel (subsp. <jats:italic>endemicum<\/jats:italic>) and yaws (subsp. <jats:italic>pertenue<\/jats:italic>; <jats:italic>TPE<\/jats:italic>). The latter is target for eradication which requires detailed information on yaws epidemiology. It has been shown that African nonhuman primates (NHPs) are infected with <jats:italic>TPE<\/jats:italic> strains that are closely related to the human infecting yaws bacterium. While human yaws infection is known to be endemic in Ghana, there is a paucity of information regarding <jats:italic>TPE<\/jats:italic> infection of Ghana's native NHPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective was to perform a small\u2010scale cross\u2010sectional serological screening for antibodies against <jats:italic>TPE<\/jats:italic> in Ghanaian monkeys. Due to the reports of <jats:italic>TPE<\/jats:italic>\u2010infected NHPs from neighbouring C\u00f4te d'Ivore, we hypothesised that monkeys in Ghana are infected with <jats:italic>TPE<\/jats:italic> and, therefore, are seropositive for antibodies against\u2010<jats:italic>Treponema<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We sampled blood from 37 NHPs representing four species: <jats:italic>Erythrocebus patas<\/jats:italic> (16\/37) 43.2%, <jats:italic>Papio anubis<\/jats:italic> (15\/37) 40.5%, <jats:italic>Chlorocebus sabaeus<\/jats:italic> (3\/37) 8.1% and <jats:italic>Cercopithecus mona<\/jats:italic> (3\/37) 8.1%. Samples were tested using the NHP validated treponemal test ESPLINE TP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 37 animals were seronegative for yaws infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We cannot exclude yaws infection in NHPs in Ghana at this point. Our study, in combination with the absence of reports of clinically infected NHPs in a yaws endemic country is, however, supportive for the current thinking that interspecies infection with <jats:italic>TPE<\/jats:italic> is extremely rare. This is an important finding for the current ongoing yaws eradication campaign.<\/jats:p><\/jats:sec>","DOI":"10.1002\/vms3.1016","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T17:59:11Z","timestamp":1670522351000},"page":"507-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No evidence for yaws infection in a small\u2010scale cross\u2010sectional serosurvey in Ghanaian monkeys"],"prefix":"10.1002","volume":"9","author":[{"given":"Eugene","family":"Adade","sequence":"first","affiliation":[{"name":"Department of Theoretical and Applied Biology Kwame Nkrumah University of Science and Technology  Kumasi Ghana"},{"name":"Kumasi Centre for Collaborative Research in Tropical Medicine Kwame Nkrumah University of Science and Technology  Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Roos","sequence":"additional","affiliation":[{"name":"Deutsches Primatenzentrum GmbH Leibniz Institute for Primate Research  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idrissa Shomari","family":"Chuma","sequence":"additional","affiliation":[{"name":"Tanzania National Parks  Arusha Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augustina Angelina","family":"Sylverken","sequence":"additional","affiliation":[{"name":"Department of Theoretical and Applied Biology Kwame Nkrumah University of Science and Technology  Kumasi Ghana"},{"name":"Kumasi Centre for Collaborative Research in Tropical Medicine Kwame Nkrumah University of Science and Technology  Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-4946","authenticated-orcid":false,"given":"Sascha","family":"Knauf","sequence":"additional","affiliation":[{"name":"Deutsches Primatenzentrum GmbH Leibniz Institute for Primate Research  G\u00f6ttingen Germany"},{"name":"Institute of International Animal Health\/One Health Friedrich\u2010Loeffler\u2010Institut  Greifswald \u2010 Insel Riems Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006303"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003016"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.20.20025122"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-52283-4_5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2406.180037"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201050779\u20109"},{"issue":"2","key":"e_1_2_11_8_1","first-page":"163","article-title":"Preliminary survey of chimpanzees and threatened monkeys in the Bia\u2010Goaso Forest Block in Southwestern Ghana","volume":"7","author":"Danquah E.","year":"2012","journal-title":"African Primates"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104614\u20107181\u20103_7"},{"key":"e_1_2_11_10_1","unstructured":"Humle T. 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