{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:33:49Z","timestamp":1784864029866,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Detomidine is an \u03b1\u20102 agonist sedative drug which reduces the release of norepinephrine in nerves. Administering this drug through intranasal (IN) route could cause direct transmission to the central nervous system. Therefore, IN administration of detomidine would decrease the side effects and the onset of sedation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In this study, IN administration of detomidine in sheep through an atomiser was compared to its IV administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifteen mature female sheep with an approximate weight of 49.53\u00a0\u00b1\u00a01.72 kg were used. They were randomly divided into three groups: (1) atomising 10\u00a0\u03bcg\/kg (IND\n                      <jats:sub>10<\/jats:sub>\n                      ); (2) IV 10\u00a0\u03bcg\/kg (IVD) and (3) atomising 30\u00a0\u03bcg\/kg (IND\n                      <jats:sub>30<\/jats:sub>\n                      ). Following administration, vital signs, electrocardiographic components, sedative score and biochemistry profile were measured after 15, 30 and 60\u00a0min, which were compared with the baseline measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bradycardia and the percentage of reduction from the baseline value in the respiratory rate were lower in the IND\n                      <jats:sub>10<\/jats:sub>\n                      group compared to those in the IVD group. There was no significant difference in terms of the temperature and blood oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) among all the groups (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). The level of cortisol declined in all the groups, and in the IND\n                      <jats:sub>30<\/jats:sub>\n                      (60\u00a0min), it was significantly different with the baseline value. The level of glucose increased in all the groups compared to the baseline, which was not significant. Insulin concentration was reduced in all the groups, and in the IND\n                      <jats:sub>30<\/jats:sub>\n                      group, it changed significantly 60\u00a0min after the drug administration. Sedation onset time was faster in the IV group. However, sedation scores between the two administration methods were not different, and only a dose\u2010dependent increase was found in the sedation score in the atomisation group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings revealed that IN atomisation of detomidine triggers similar sedation as its IV administration, which could be used as an alternative method.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1023","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T12:58:30Z","timestamp":1670504310000},"page":"353-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparing the effects of intravenous injection and intranasal atomisation of detomidine in sheep"],"prefix":"10.1002","volume":"9","author":[{"given":"Touran","family":"Tahmasbi","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Clinical Sciences, Lorestan University  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-4284","authenticated-orcid":false,"given":"Abbas","family":"Raisi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Clinical Sciences, Lorestan University  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7535-4749","authenticated-orcid":false,"given":"Amir","family":"Zakian","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Clinical Sciences, Lorestan University  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Khaldari","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Department of Animal Husbandry, Lorestan University  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(83)90417-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-022-03194-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00542.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)32565-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/81.2.208"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.1997.00097.x"},{"key":"e_1_2_10_8_1","volume-title":"Veterinary medicine\u2010e\u2010book: A textbook of the diseases of cattle, horses, sheep, pigs and goats","author":"Constable P. 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