{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:59:38Z","timestamp":1788242378610,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The long\u2010term clinical and biofhemical effects of basal\u2010bolus insulin treatment with lispro and NPH in dogs with diabetes mellitus are undocumented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To perform a prospective pilot field study of the long\u2010term effects of lispro and NPH on clinical signs and serum fructosamine concentrations (SFC) in dogs with diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve dogs received combined lispro and NPH insulins treatment twice a day and were examined every 2 weeks for 2 months (visits 1\u20134), and every 4 weeks for up to 4 additional months (visits 5\u20138). Clinical signs and SFC were recorded at each visit. Polyuria and polydipsia (PU\/PD) were scored as absent (0) or present (1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median (range) PU\/PD scores of combined visits 5\u20138 (0, 0\u20131) were significantly lower than median scores of combined visits 1\u20134 (1, 0\u20131,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03) and at enrolment (1, 0\u20131,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.045). Median (range) SFC of combined visits 5\u20138 (512\u00a0mmol\/L, 401\u2013974\u00a0mmol\/L) was significantly lower than SFC of combined visits 1\u20134 (578\u00a0mmol\/L, 302\u2013996\u00a0mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002) and at enrolment (662\u00a0mmol\/L, 450\u2013990\u00a0mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). Lispro insulin dose was significantly and negatively, albeit weakly, correlated with SFC concentration during visits 1 through 8 (\n                      <jats:italic>r<\/jats:italic>\n                      = \u20130.3,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013). Median duration of follow up was 6 months (range 0.5\u20136) and most dogs (8, 66.7%) were followed for 6 months. Four dogs withdrew from the study within 0.5\u20135 months because of documented or suspected hypoglycaemia, short NPH duration or sudden unexplained death. Hypoglycaemia was noted in 6 dogs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long\u2010term lispro and NPH combination therapy may improve clinical and biochemical control of some diabetic dogs with comorbidities. Risk of hypoglycaemia should be addressed with close monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1077","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T10:45:52Z","timestamp":1676544352000},"page":"704-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term field study of lispro and neutral protamine Hagedorn insulins treatment in dogs with diabetes mellitus"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7130-1706","authenticated-orcid":false,"given":"Sharon","family":"Kuzi","sequence":"first","affiliation":[{"name":"Department of Small Animals Internal Medicine Koret School of Veterinary Medicine Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Mazaki\u2010Tovi","sequence":"additional","affiliation":[{"name":"Department of Small Animals Internal Medicine Koret School of Veterinary Medicine Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Hershkovitz","sequence":"additional","affiliation":[{"name":"Department of Small Animals Internal Medicine Koret School of Veterinary Medicine Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einat","family":"Yas","sequence":"additional","affiliation":[{"name":"Department of Small Animals Internal Medicine Koret School of Veterinary Medicine Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecka S.","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences &amp; 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