{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:16:24Z","timestamp":1772118984099,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007103","name":"Semnan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Induction of parturition in guinea pigs appears to be essential because these animals have a higher rate of reproductive problems than rabbits and small rodents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Since aglepristone (AGL) is a competitive progesterone antagonist acting through binding to progesterone receptors while oxytocin (OT) is a powerful constituent of uterine smooth muscle, the aim of this study was to evaluate the clinical and ultrasonographic impacts of AGL and OT on guinea pig parturition induction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, guinea pigs were allocated into five groups; each included five animals on the 61st day of pregnancy. In the aglepristone group (Agle), AGL was administrated subcutaneously (SC) once daily on 2 consecutive days (Days 61 and 62 post mating). Oxytocin (OT) was administered subcutaneously once and twice at 4\u2010h intervals on Day 62 post mating in oxytocin 1 (Oxy1) and oxytocin 2 (Oxy2) groups, respectively. The animals in the aglepristone\u2010oxytocin group (Agle\u2010Oxy) received AGL subcutaneously once daily on 2 consecutive days (Days 61 and 62 post mating) and OT on Day 62 post mating. The remaining sows received saline solution (0.9% NaCl) in the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      According to the results, fetal heart rate, temperature, neonatal and maternal survival rates were not significantly different between the treatment and control groups (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). Biparietal diameter of head and body weight of neonates in the Agle, Oxy2 and Agle\u2010Oxy groups showed a significant decline, compared to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). The time interval between injection and delivery and the duration of pregnancy was significantly reduced in Agle, Oxy2, Agl\u2010Oxy groups, compared to the control and Oxy1 groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, it seems that treatment Oxy2 can induce parturition in guinea pigs without side effects and lower pain during induction of parturition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1078","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T15:04:30Z","timestamp":1673535870000},"page":"1297-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of aglepristone and oxytocin on induction of parturition in guinea pig"],"prefix":"10.1002","volume":"9","author":[{"given":"Tayeban","family":"Sara","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine Semnan University  Semnan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narenjisani","family":"Reza","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Semnan University  Semnan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5564-9339","authenticated-orcid":false,"given":"Keywanloo","family":"Morteza","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Semnan University  Semnan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasamin","family":"Vali","sequence":"additional","affiliation":[{"name":"Diagnostic imaging, Departement of Companion Animals and Horses University of Veterinary Medicine Vienna (Vetmeduni)  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0975-6731","authenticated-orcid":false,"given":"Sarang","family":"Soroori","sequence":"additional","affiliation":[{"name":"Department of Surgery and Radiology, Faculty of Veterinary Medicine University of Tehran  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahroozian","family":"Ebrahim","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Faculty of Veterinary Medicine Semnan University  Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12926"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolreprod\/22.5.1106"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2007.10.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174414000592"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2016.07.028"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.02.020"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.10.2093"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2009.01419.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2009.01377.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2015.10.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118997215"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.applanim.2011.10.020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367774781005850"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2005.04.012"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2016.12.028"},{"issue":"1","key":"e_1_2_9_17_1","first-page":"10","article-title":"Oxytocin in the treatment of dystocia in mice","volume":"51","author":"Narver H. 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