{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:16:24Z","timestamp":1772118984090,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ocular hypertension is one of the most underdiagnosed ocular abnormalities among guinea pigs around the world.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The current study investigates the effect of 0.0015% preservative\u2010free tafluprost ophthalmic solution (Zioptan) on the intraocular pressure of 16 healthy male guinea pigs (\n                      <jats:italic>Cavia porcellus<\/jats:italic>\n                      ) under different light\/darkness regimes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All guinea pigs received a single drop of tafluprost at 5:30 in the right eye, whereas the contralateral eyes served as control to receive a placebo. Then, the animals were randomly divided into two groups; group A was exposed to light, whereas group B was placed in darkness from 5:30 to 18:00. Rebound tonometry (TonoVet) was instrumented to measure IOP values at 5:30 (baseline), 6:00, 7:00, 8:00, 9:00 and then every 3\u00a0h until 18:00.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The maximum IOP reduction associated with tafluprost was observed at 6:00 by \u22121.4\u00a0\u00b1\u00a01.1\u00a0mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u00a0=\u00a00.026) and \u22122.5\u00a0\u00b1\u00a01.2\u00a0mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u00a0=\u00a00.011) in group A and B, respectively (repeated measure ANOVA test). There was a significant difference between the mean right and left eye IOP values in both groups at 5:30, 6:00, 7:00 and 8:00 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value &lt;0.05), which was greater in amount in group B compared to group A due to the effect of darkness on IOP reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It is suggested that the variations of IOP in different light\/dark conditions be taken into consideration when applying ocular hypotensive agents on guinea pigs\u2019 eyes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1082","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T08:10:21Z","timestamp":1675930221000},"page":"1172-1178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The evaluation of the effect of tafluprost on the intraocular pressure of healthy male guinea pigs under different light\u2010and\u2010darkness regimes"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-0933","authenticated-orcid":false,"given":"Arghavan","family":"Armin","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences The Science and Research Branch of Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-5977","authenticated-orcid":false,"given":"Farnoosh","family":"Arfaee","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences The Science and Research Branch of Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Ozmaie","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences The Science and Research Branch of Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Asghari","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences The Science and Research Branch of Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2003.08.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2009.0100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2009.0006"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"95","article-title":"Twenty\u2010four\u2013hour measurement of intraocular pressure in guinea pigs (Cavia porcellus)","volume":"55","author":"Ansari\u2010Mood M.","year":"2016","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"issue":"8","key":"e_1_2_10_6_1","first-page":"785","article-title":"Intraocular pressure of rhesus monkey (Macaca mulatta). 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