{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:35:10Z","timestamp":1782462910436,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T00:00:00Z","timestamp":1448236800000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Feline immunodeficiency virus (<jats:styled-content style=\"fixed-case\">FIV<\/jats:styled-content>) is a lentivirus that can lead to a syndrome of acquired immune dysfunction. Infected cats often remain asymptomatic for several years before immune dysfunction leads to an increased risk for the development of systemic diseases, neoplasia and opportunistic infections. FIV is structurally related to human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>) and the pathogenesis of<jats:styled-content style=\"fixed-case\">FIV<\/jats:styled-content>\u2010related disease is similar to that seen in<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients. Observational studies have documented an association between low plasma vitamin D and<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>infection. Vitamin D status has been shown to be associated with<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010related disease progression, morbidity and mortality. The objective of this study was to examine the hypothesis that vitamin D status, as assessed by serum 25\u2010hydroxyvitamin D [25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D] concentrations, are lower in cats with<jats:styled-content style=\"fixed-case\">FIV<\/jats:styled-content>infection compared to healthy control cats. Serum 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D concentrations were measured in 20 healthy cats, 39 hospitalized ill cats and 59 cats infected with<jats:styled-content style=\"fixed-case\">FIV<\/jats:styled-content>. Cats which were<jats:styled-content style=\"fixed-case\">FIV<\/jats:styled-content>infected had significantly lower 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D concentrations compared to healthy control cats. Serum 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D concentrations were not significantly different between<jats:styled-content style=\"fixed-case\">FIV<\/jats:styled-content>\u2010infected cats and hospitalized ill cats. Further investigations are warranted to determine whether vitamin D status influences the prognosis of cats infected with<jats:styled-content style=\"fixed-case\">FIV<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/vms3.11","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T03:42:49Z","timestamp":1448336569000},"page":"72-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Vitamin D status in cats with feline immunodeficiency virus"],"prefix":"10.1002","volume":"1","author":[{"given":"Helen F.","family":"Titmarsh","sequence":"first","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies and the Roslin Institute University of Edinburgh Roslin Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Lalor","sequence":"additional","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies and the Roslin 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