{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:57:46Z","timestamp":1782734266456,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dysregulation of the estrogen receptor 1 (ESR1) expression during the establishment of pregnancy could contribute to reduce fertility reported in ewes treated with PG\u2010600.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate the effect of treatment with PG\u2010600 on ESR1 expression in the ovine endometrium during early diestrus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Polypay ewes (\n                      <jats:italic>n<\/jats:italic>\n                      = 24) that had exhibited an oestrous cycle of normal duration (16\u201318 days) were treated with intravaginal progesterone\u2010releasing device (CIDR) for 9 days. Cloprostenol was administrated two days before CIDR withdrawal. On the day of CIDR withdrawal (day 0), ewes received a 5\u00a0mL intramuscular injection of PG\u2010600 (400 IU equine chorionic gonadotropin and 200 IU human chorionic gonadotropin) or saline. Blood samples were collected before treatment and on the day of tissue collection to determine serum estradiol\u201017\u03b2 and progesterone concentrations using radioimmunoassay. On days 4 and 7, six ewes from each treatment group were anaesthetised and a laparotomy was performed to obtain intercaruncular endometrial samples. Endometrial samples were collected ipsilateral to the ovary bearing the highest number of corpora lutea. An estradiol exchange assay was used to determine ESR1 concentration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Estradiol concentrations did not differ by time or treatment, but progesterone concentrations were significantly higher in the PG\u2010600\u2010treated group on day 7 despite a similar number of corpora lutea. Endometrial ESR1 concentration was significantly reduced on day 7 in the PG\u2010600 group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, although progesterone was higher than controls on day 7, ESR1 did not differ from controls suggesting that treatment with PG600 is unlikely to impair reproductive potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1119","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T12:48:28Z","timestamp":1678884508000},"page":"1379-1384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ovine endometrial estrogen receptor expression is altered following PG\u2010600 administration"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0229-9523","authenticated-orcid":false,"given":"Hayder Mohammed Hassan","family":"Habeeb","sequence":"first","affiliation":[{"name":"Department of Animal Production Al\u2010Qasim Green University  Babylon Iraq"},{"name":"Department of Animal and Rangeland Sciences Oregon State University  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"Kleditz","sequence":"additional","affiliation":[{"name":"College of Engineering Oregon State University  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Hazzard","sequence":"additional","affiliation":[{"name":"Department of Animal and Rangeland Sciences Oregon State University  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecily","family":"Bishop","sequence":"additional","affiliation":[{"name":"Department of Animal and Rangeland Sciences Oregon State University  Corvallis Oregon USA"},{"name":"Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center Oregon Health &amp; Science University  Beaverton Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Stormshak","sequence":"additional","affiliation":[{"name":"Department of Animal and Rangeland Sciences Oregon State University  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Anne","family":"Kutzler","sequence":"additional","affiliation":[{"name":"Department of Animal and Rangeland Sciences Oregon State University  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005\u20100869"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0620315"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201014\u20100632"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/tas\/txy092"},{"key":"e_1_2_9_6_1","unstructured":"Estienne M. 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