{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:05:59Z","timestamp":1791950759574,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pyelonephritis is a serious condition that is rarely described in horses. In contrast, urinary tract infections are common in humans and small animals, and multi\u2010drug\u2010resistant urinary infections are an emerging threat. In this report, we describe a horse with unilateral pyelonephritis caused by extended\u2010spectrum beta\u2010lactamase\u2010producing bacteria belonging to the\n                    <jats:italic>Enterobacter cloacae<\/jats:italic>\n                    complex. [Correction added on 9 August 2023, after first online publication: The preceding sentence was corrected.] An 11\u2010year\u2010old Swedish warmblood gelding was diagnosed with a cystolith and a cystotomy through an open left para\u2010inguinal approach was performed. Seven days after surgery the horse presented with pyrexia, dullness and colic. Diagnostic testing and renal transabdominal ultrasonography confirmed the presence of a right\u2010sided pyelonephritis. Culture and antimicrobial susceptibility testing revealed a pure growth of extended\u2010spectrum beta\u2010lactamases\u2010producing\n                    <jats:italic>E. cloacae<\/jats:italic>\n                    complex bacteria with resistance against beta\u2010lactams, aminoglycoside and trimethoprim\u2013sulphonamide classes. Treatment included prolonged oral antimicrobials according to susceptibility testing results (enrofloxacin), judicious use of non\u2010steroidal anti\u2010inflammatory drugs, fluid therapy and gastric ulcer prophylaxis. The horse recovered successfully and is currently in good health (follow\u2010up of 5 years). Once the infection resolved, unilateral renal scarring occurred. Multidrug\u2010resistant upper\u2010urinary infections occur in horses and should be considered in a post\u2010surgical patient that develops fever. Early diagnosis, urine bacterial culturing and antimicrobial susceptibility testing were crucial in this case to successful management.\n                  <\/jats:p>","DOI":"10.1002\/vms3.1201","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T06:37:32Z","timestamp":1689748652000},"page":"2042-2052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Do post\u2010surgical multiresistant urinary infections occur in horses? Case of unilateral pyelonephritis caused by extended\u2010spectrum beta\u2010lactamase\u2010producing bacteria as a complication of cystotomy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0658-8207","authenticated-orcid":false,"given":"Elisa","family":"Scala","sequence":"first","affiliation":[{"name":"Evidensia Specialisth\u00e4stsjukhuset Str\u00f6msholm Str\u00f6msholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0689-7141","authenticated-orcid":false,"given":"Gaby","family":"van Galen","sequence":"additional","affiliation":[{"name":"Sydney School of Veterinary Science University of Sydney Sydney New South Wales Australia"},{"name":"Goulburn Valley Equine Hospital Congupna Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-1025","authenticated-orcid":false,"given":"Elin M.","family":"Sk\u00e4rlina","sequence":"additional","affiliation":[{"name":"Evidensia Specialisth\u00e4stsjukhuset Str\u00f6msholm Str\u00f6msholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5174-7126","authenticated-orcid":false,"given":"Inge","family":"Durie","sequence":"additional","affiliation":[{"name":"Evidensia Specialisth\u00e4stsjukhuset Str\u00f6msholm Str\u00f6msholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TVJL.2017.05.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2019.1680052"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14836"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010014\u20100639\u20104"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20100813.1987.tb09696.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.12809\/hkmj134061"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00002\u201019"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/AJVR.67.2.310"},{"key":"e_1_2_10_10_1","first-page":"398","volume-title":"Textbook of Veterinary Internal Medicine","author":"Ettinger S. 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