{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:26:11Z","timestamp":1784759171046,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      1,25\u2010Dihydroxyvitamin D (1,25(OH)\n                      <jats:sub>2<\/jats:sub>\n                      D) is vital in the homeostasis of calcium and bone health as well as in the prevention of many disorders such as neoplasms. Epidemiological data show that low concentrations of both 1,25(OH)\n                      <jats:sub>2<\/jats:sub>\n                      D and its precursor 25(OH) vitamin D (25(OH)D) are associated with an increased risk of a variety of human tumours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate 25(OH)D, parathormone (PTH) and immunity marker concentrations in dogs with transmissible venereal tumour (TVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      25(OH)D, PTH and various biochemical and immunity markers were evaluated in dogs with TVT (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a026) and in healthy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030) dogs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>25(OH)D concentrations were significantly lower in dogs with TVT in comparison with healthy dogs. In contrast, PTH, immunoglobulin G and interleukin (IL)\u20109 concentrations were higher in the dogs with TVT. Other variables, including IL\u201010, interferon \u03b3, calcium and inorganic phosphate, were not statistically different between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Decreased serum 25(OH)D concentration may be a risk factor for the development of canine TVT; however, cause\u2010and\u2010effect remains incompletely understood. Further studies are required to elucidate the exact role of 25(OH)D in canine TVT and whether vitamin D supplementation may be useful prophylactically or as an adjunct to chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1235","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T04:38:27Z","timestamp":1691037507000},"page":"2026-2031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of serum 25(OH) vitamin D, parathormone and immunity marker concentrations between dogs with transmissible venereal tumour and healthy dogs"],"prefix":"10.1002","volume":"9","author":[{"given":"Helia Kamali","family":"Sadeghian","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine Ferdowsi University of Mashhad Mashhad 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