{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:47:37Z","timestamp":1751431657010,"version":"3.40.5"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T00:00:00Z","timestamp":1694217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to evaluate the diagnostic efficacies of selected inflammatory and intestinal biomarkers in cases of infectious and non\u2010infectious diarrhoea in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 60 dogs, 12 healthy (Control Group) and 48 with diarrhoea were used. Viral, Bacterial, Parasitic (infectious) and Nutritional diarrhoea (non\u2010infectious) subgroups (<jats:italic>n<\/jats:italic>: 12) were formed according to the aetiology, on the basis of clinical and laboratory examinations. Selected inflammatory and intestinal biomarkers (Calgranulin, S100A12; Lactoferrin, LCTF; C\u2010reactive protein, CRP) were measured both in serum and faecal samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the Control and Nutritional Diarrhoea groups, the infectious diarrhoea groups had higher serum S100A12, LCTF, CRP, blood urea nitrogen, creatinine (CR), alanine transaminase and alkaline phosphatase, and lower glucose (GLU), sodium (Na) and potassium (K) concentrations (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05); Viral and Parasitic Diarrhoea groups had lower serum albumin (ALB) and total protein (TP) concentrations (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Faecal S100A12, LCTF and CRP concentrations were higher in infectious diarrhoea groups compared to the Control and Nutritional Diarrhoea groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Faecal LCTF and CRP concentrations were higher in the Bacterial Diarrhoea group than in the Viral and Parasitic Diarrhoea groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>It was determined that serum (area under curve, AUC: 0.842 and 0.956) and faecal (AUC: 0.975 and 0.786) S100A12 and CRP concentrations in viral diarrhoea; serum (AUC: 0.956) and faecal (AUC: 0.992) LCTF concentrations in bacterial diarrhoea have diagnostic values in the diagnosis of the presence of intestinal inflammation and damage and can be used in the differential diagnosis of infectious and non\u2010infectious diarrhoea.<\/jats:p><\/jats:sec>","DOI":"10.1002\/vms3.1245","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T17:53:40Z","timestamp":1694282020000},"page":"2485-2496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum\/Faecal S100A12, CRP and lactoferrin can be used to distinguish \u0131nfectious and non\u2010\u0131nfectious canine diarrhoea"],"prefix":"10.1002","volume":"9","author":[{"given":"Mehmet","family":"Maden","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Veterinary Faculty Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-0150","authenticated-orcid":false,"given":"Erdem","family":"G\u00fclersoy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Veterinary Faculty Harran University  \u015eanl\u0131urfa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2016.12.004"},{"key":"e_1_2_10_3_1","first-page":"183","volume-title":"Small animal gastroenterology","author":"Allenspach K.","year":"2008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03011.x"},{"key":"e_1_2_10_5_1","first-page":"972","article-title":"Haemato\u2010biochemical alterations in gastroenteritis affected dogs","volume":"6","author":"Arora R.","year":"2018","journal-title":"Journal of Entomology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2011.01.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1905-x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2017.12.009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217750088"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9080725"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i37.4218"},{"key":"e_1_2_10_12_1","first-page":"1964","article-title":"Alpha\u20101\u2010antitrypsin therapy ameliorates acute colitis and chronic murine ileitis","volume":"19","author":"Collins C. 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