{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:31:29Z","timestamp":1788787889323,"version":"build-2803163510"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe a case of 5\u2010hydroxytryptophan (5\u2010HTP) toxicity successfully treated with haemodialysis in a dog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>A 3\u2010year\u2010old, male neutered Labrador Retriever, weighing 28.2\u00a0kg, presented to the emergency department approximately 4\u20135\u00a0h after ingesting a human supplement containing 200\u00a0mg of 5\u2010HTP. The amount of 5\u2010HTP ingested was estimated between 980 and 1988\u00a0mg (35\u201371\u00a0mg\/kg). At presentation, the dog demonstrated progressive neurologic abnormalities consistent with serotonin syndrome, including altered mentation and ataxia. Due to the magnitude of the ingested dose and progression of clinical signs, extracorporeal blood purification with intermittent haemodialysis was chosen to expedite clearance of 5\u2010HTP. High\u2010efficiency haemodialysis was initiated, and the dog showed continued clinical improvement throughout the 5\u2010h treatment. Clinical signs resolved completely within 12\u00a0h. Sequential blood and urine samples were obtained to document levels of both 5\u2010HTP and serotonin. The dog was discharged 24\u00a0h after presentation with complete resolution of clinical signs.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information<\/jats:title><jats:p>This is the first report documenting the serial changes in 5\u2010HTP concentrations during treatment with haemodialysis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/vms3.1253","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T16:23:52Z","timestamp":1693671832000},"page":"2438-2442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["5\u2010Hydroxytryptophan toxicity successfully treated by haemodialysis in a dog"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7326-2082","authenticated-orcid":false,"given":"Diana Victoria","family":"Arbona","sequence":"first","affiliation":[{"name":"Veterinary Specialty Hospital by Ethos Veterinary Health  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry D.","family":"Cowgill","sequence":"additional","affiliation":[{"name":"Advanced Extracorporeal and Urinary Disease Service UC Veterinary Medical Center\u2014San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saya","family":"Press","sequence":"additional","affiliation":[{"name":"Veterinary Specialty Hospital by Ethos Veterinary Health  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Dufayet","sequence":"additional","affiliation":[{"name":"Advanced Extracorporeal and Urinary Disease Service UC Veterinary Medical Center\u2014San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Istvan","sequence":"additional","affiliation":[{"name":"Veterinary Specialty Hospital by Ethos Veterinary Health  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12899"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"93","article-title":"Lipid therapy for serotonin syndrome after intoxication with venlafaxine, lamotrigine and diazepam","volume":"77","author":"Dagtekin O.","year":"2011","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(98)00057-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.216.1937"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-017-0600-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02560319"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1980.tb02451.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01061381"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2008.00944.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2010.09.005"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.1253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T21:38:16Z","timestamp":1700084296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.1253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,2]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/vms3.1253"],"URL":"https:\/\/doi.org\/10.1002\/vms3.1253","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,2]]},"assertion":[{"value":"2023-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}