{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:43:23Z","timestamp":1775281403782,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18im0210812h0101"],"award-info":[{"award-number":["JP18im0210812h0101"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Photodynamic therapy (PDT) using photosensitisers is a minimally invasive treatment for malignant tumours. However, ideal photosensitisers are not yet established. Recently, we developed a new photosensitiser, glucose\u2010conjugated chlorin e6 (G\u2010Ce6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy of vascular\u2010targeted PDT (VTP), a type of PDT utilising a short drug\u2010light interval, using G\u2010Ce6 to treat spontaneously occurring tumours in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five dogs with spontaneously occurring tumours (malignant melanoma: three; haemangiopericytoma: two; and squamous cell carcinoma: one) were subjected to VTP. These dogs were intravenously injected with G\u2010Ce6 at doses of 1\u20133\u00a0mg\/kg 5\u00a0min before laser irradiation. Tumours were superficially or interstitially irradiated using a 677\u2010nm diode laser.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Repeated VTP decreased tumour size, yielding complete remission in three dogs. Complications such as oedema surrounding normal tissues and fistulae were observed, and the oedema was self\u2010limiting. The fistula was cured by debriding the necrotic tissues formed after VTP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate that VTP using G\u2010Ce6 had antitumour effects in dogs with spontaneously occurring tumours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1263","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T05:38:47Z","timestamp":1694842727000},"page":"2534-2541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vascular\u2010targeted photodynamic therapy with glucose\u2010conjugated chlorin e6 for dogs with spontaneously occurring tumours"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2689-9435","authenticated-orcid":false,"given":"Tomohiro","family":"Osaki","sequence":"first","affiliation":[{"name":"Faculty of Agriculture Joint Department of Veterinary Clinical Medicine, Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Hibino","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Joint Department of Veterinary Clinical Medicine, Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Murahata","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Joint Department of Veterinary Clinical Medicine, Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Amaha","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Joint Department of Veterinary Clinical Medicine, Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inoru","family":"Yokoe","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Joint Department of Veterinary Clinical Medicine, Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Joint Department of Veterinary Clinical Medicine, Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Nomoto","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Graduate School of Engineering Osaka Metropolitan University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigenobu","family":"Yano","sequence":"additional","affiliation":[{"name":"KYOUSEI Science Center for Life and Nature Institute of Yamato Area and Kii Peninsula Nara Women's University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiharu","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Joint Department of Veterinary Clinical Medicine, Tottori University  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1328"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201039036\u20101"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2017.11.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/app122312276"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.691697"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21091"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040841"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020353"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm\u20102018\u20100255"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12677"},{"key":"e_1_2_11_12_1","first-page":"179","volume-title":"Small animal surgery","author":"MacPhail C. M.","year":"2019"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1142\/s1088424619300180"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12032"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25225417"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3987\/COM\u201020\u2010S(K)73"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph3051507"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050636"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439\u20100442.2006.00802.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2006.05.021"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.71.125"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010018\u20100210\u2010y"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9020012"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010019\u20100475\u20101"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9020019"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119089124.ch4"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132785"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.1263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T16:39:56Z","timestamp":1700066396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.1263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,16]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/vms3.1263"],"URL":"https:\/\/doi.org\/10.1002\/vms3.1263","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/VMS3.1263\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1263\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1263\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1263\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1263\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1263\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1263\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1263\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1263\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1263\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1263\/v3\/decision1","asserted-by":"object"}]},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,16]]},"assertion":[{"value":"2023-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}