{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:25:07Z","timestamp":1789590307080,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Open spina bifida is an uncommon malformation in animals, and there is a lack of imaging, clinical, and pathological characterisation of this condition in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Open spina bifida is rarely observed in animals due to high levels of perinatal mortality and frequent euthanasia. To the best of our knowledge, we present the first case of spina bifida in a dog was diagnosed in\u2010utero and then followed post\u2010partum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 3\u2010year\u2010old Poodle was presented with twin pregnancy. Radiographic and ultrasonographic findings were suggestive of vertebral malformation and open spina bifida with myelomeningocele in one foetus. Conservative treatment was given but the puppy died 3 days after birth. Thereafter, anatomical and histopathological analysis of several organs was performed to characterise the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When the twins were born, one puppy had a linear dorsal midline cutaneous defect extending from the level of vertebrae L2\u2013L6. R Radiographic examination showed several congenital vertebral malformations involving the thoracic segment, lumbar segment, sacrum and scapula. Histopathological examinations confirmed the presence of open spina bifida and identified additional abnormalities in several internal organs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case presents a complete characterisation of open spina bifida, before birth and after death, using imaging and histopathology techniques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1266","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:26:01Z","timestamp":1694683561000},"page":"2452-2457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Open spina bifida characterisation in a dog foetus"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7051-2365","authenticated-orcid":false,"given":"Yue","family":"Chen","sequence":"first","affiliation":[{"name":"Chengdu Bio\u2010HT Company Limited  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1009-0607","authenticated-orcid":false,"given":"Dan","family":"Su","sequence":"additional","affiliation":[{"name":"Chengdu Bio\u2010HT Company Limited  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-854X","authenticated-orcid":false,"given":"Xiaorong","family":"Sun","sequence":"additional","affiliation":[{"name":"Chengdu Bio\u2010HT Company Limited  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3989-1229","authenticated-orcid":false,"given":"Wenjuan","family":"Gui","sequence":"additional","affiliation":[{"name":"General Hospital of Ningxia Medical University  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-10-54"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13240"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.192518"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.25259\/SNI_84_2020"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1995.tb02877.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01062.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638719827626"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13342"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17445-X"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513815.2019.1651799"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2021.04.013"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.100314"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-016-2298-6"},{"key":"e_1_2_10_15_1","first-page":"1133","article-title":"Myelomeningocoele and a dermoid sinus\u2010like lesion in a French Bulldog","volume":"54","author":"Ployart S.","year":"2013","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.7.FOCUS19406"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0963180119000409"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-020-04824-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.4.PEDS18383"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1995.tb00382.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.148.24.755"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002348R"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e31828c5f88"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.1266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T16:41:39Z","timestamp":1700066499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.1266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/vms3.1266"],"URL":"https:\/\/doi.org\/10.1002\/vms3.1266","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/VMS3.1266\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v5\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v6\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v6\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v6\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v4\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v5\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v5\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1266\/v4\/response1","asserted-by":"object"}]},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]},"assertion":[{"value":"2022-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}