{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:45:34Z","timestamp":1762609534201,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Displaced abomasum (DA) is one of the most important metabolic disorders of dairy cattle. In DA, ischaemic damage may occur as a result of impaired perfusion due to abomasal displacement, which may result in gastrointestinal mucosal damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Investigation of gastrointestinal tissue damage in cattle with right displacement of the abomasum (RDA) and left displacement of the abomasum (LDA) using intestinal\u2010related biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight DA (24 LDA, 24 RDA) and 15 healthy Holstein dairy cows were enrolled between March 2021 and July 2022. Serum biomarkers including gamma\u2010enteric smooth muscle actin (ACTG\u20102), liver\u2010fatty acid binding proteins (L\u2010FABP), platelet activating factor (PAF), trefoil factor\u20103 (TFF\u20103), leptin, claudin\u20103 and interleukin\u20108 (IL\u20108) concentrations were measured from venous blood samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>L\u2010FABP concentrations in the LDA group and TFF\u20103 concentrations in the RDA group were lower than in the control group. The leptin concentration of the RDA group was higher than that of the other groups. There was a negative correlation between lactate, leptin and IL\u20108 concentrations. There was a negative correlation between lactate and TFF\u20103, whereas leptin and lactate were positively correlated. Leptin was the more reliable biomarker for discriminating between RDA and LDA cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Changes in serum L\u2010FABP, TFF\u20103 and leptin concentrations in cattle with DA may reflect acute intestinal injury and the subsequent repair phase. However, these biomarkers had poor diagnostic performance in discriminating between healthy and cattle with DA, while leptin emerged as the most useful marker in differentiating LDA from RDA cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/vms3.1292","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T12:20:23Z","timestamp":1696076423000},"page":"2893-2900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigation of gastrointestinal injury\u2010related biomarkers in dairy cattle with displaced abomasum"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-5452","authenticated-orcid":false,"given":"Merve","family":"Ider","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Internal Medicine Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-0891","authenticated-orcid":false,"given":"Ramazan","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Internal Medicine Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-5879","authenticated-orcid":false,"given":"Amir","family":"Naseri","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Internal Medicine Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-0150","authenticated-orcid":false,"given":"Erdem","family":"G\u00fclersoy","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Internal Medicine Harran University  Sanl\u0131urfa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-1903","authenticated-orcid":false,"given":"Fahrettin","family":"Alkan","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Surgery Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8210-6735","authenticated-orcid":false,"given":"Mahmut","family":"Ok","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Internal Medicine Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4271-7953","authenticated-orcid":false,"given":"Alper","family":"Erturk","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Internal Medicine Mustafa Kemal University  Hatay Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-8185","authenticated-orcid":false,"given":"Kadir","family":"Sulu","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Internal Medicine Siirt University  Siirt Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-8536","authenticated-orcid":false,"given":"Murat Kaan","family":"Durgut","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Internal Medicine Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191593"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-204X2008000100018"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182222f67"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-3-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2003.10.019"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/568343"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13360"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.19-0378"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-5-37"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/0471722146","volume-title":"Applied logistic regression","author":"Hosmer D. 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